E
Emilia L. Lim
Researcher at Francis Crick Institute
Publications - 57
Citations - 5346
Emilia L. Lim is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 17, co-authored 35 publications receiving 3876 citations. Previous affiliations of Emilia L. Lim include University College London & BC Cancer Agency.
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Journal ArticleDOI
HMDB: a knowledgebase for the human metabolome
David S. Wishart,Craig Knox,An Chi Guo,Roman Eisner,Nelson Young,Bijaya Gautam,David Hau,Nick Psychogios,Edison Dong,Souhaila Bouatra,Rupasri Mandal,Igor Sinelnikov,Jianguo Xia,Leslie Jia,Joseph A. Cruz,Emilia L. Lim,Constance A. Sobsey,Savita Shrivastava,Paul Huang,Philip Liu,Lydia Fang,Jun Peng,Ryan Fradette,Dean Cheng,Dan Tzur,Melisa Clements,Avalyn Lewis,Andrea De Souza,Azaret Zuniga,Margot Dawe,Yeping Xiong,Derrick L. J. Clive,Russell Greiner,Alsu Nazyrova,Rustem Shaykhutdinov,Liang Li,Hans J. Vogel,Ian J. Forsythe +37 more
TL;DR: The most recent release of HMDB has been significantly expanded and enhanced over the previous release, with the number of fully annotated metabolite entries growing from 2180 to more than 6800, a 300% increase.
Journal ArticleDOI
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
Caleb F. Davis,Christopher J. Ricketts,Min Wang,Lixing Yang,Andrew D. Cherniack,Hui Shen,Christian J. Buhay,Hyojin Kang,Sang Cheol Kim,Catherine C. Fahey,Kathryn E. Hacker,Gyan Bhanot,Dmitry A. Gordenin,Andy Chu,Preethi H. Gunaratne,Preethi H. Gunaratne,Michael Biehl,Sahil Seth,Benny Abraham Kaipparettu,Christopher A. Bristow,Lawrence A. Donehower,Eric Wallen,Angela B. Smith,Satish K. Tickoo,Pheroze Tamboli,Victor E. Reuter,Laura S. Schmidt,James J. Hsieh,James J. Hsieh,Toni K. Choueiri,A. Ari Hakimi,Chad J. Creighton,Margaret Morgan,David A. Wheeler,Richard A. Gibbs,Sabina Signoretti,A. Gordon Robertson,Elizabeth P. Henske,David J. Kwiatkowski,Christopher J. Ricketts,W. Marston Linehan,Michael P. Seiler,W. Kimryn Rathmell,Peter W. Laird,Brian Shuch,Donna M. Muzny,Hsu Chao,Mike Dahdouli,Liu Xi,Nipun Kakkar,Jeffrey G. Reid,Brittany Downs,Jennifer Drummond,Donna Morton,Harsha Doddapaneni,Lora Lewis,Adam C. English,Qingchang Meng,Christie Kovar,Qiaoyan Wang,Walker Hale,Alicia Hawes,Divya Kalra,Kimberly Walker,Bradley A. Murray,Carrie Sougnez,Gordon Saksena,Scott L. Carter,Steven E. Schumacher,Barbara Tabak,Travis I. Zack,Gad Getz,Rameen Beroukhim,Stacey Gabriel,Matthew Meyerson,Adrian Ally,Miruna Balasundaram,Inanc Birol,Denise Brooks,Yaron S.N. Butterfield,Eric Chuah,Amanda Clarke,Noreen Dhalla,Ranabir Guin,Robert A. Holt,Katayoon Kasaian,Darlene Lee,Haiyan I. Li,Emilia L. Lim,Yussanne Ma,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Tina Wong,Steven J.M. Jones,Marco A. Marra,J. Todd Auman,Donghui Tan,Shaowu Meng,Corbin D. Jones,Katherine A. Hoadley,Piotr A. Mieczkowski,Lisle E. Mose,Stuart R. Jefferys,Jeffrey Roach,Umadevi Veluvolu,Matthew D. Wilkerson,Scot Waring,Elizabeth Buda,Junyuan Wu,Tom Bodenheimer,Alan P. Hoyle,Janae V. Simons,Mathew G. Soloway,Saianand Balu,Joel S. Parker,D. Neil Hayes,Charles M. Perou,Daniel J. Weisenberger,Moiz S. Bootwalla,Timothy J. Triche,Phillip H. Lai,David Van Den Berg,Stephen B. Baylin,Fengju Chen,Cristian Coarfa,Michael S. Noble,Daniel DiCara,Hailei Zhang,Juok Cho,David I. Heiman,Nils Gehlenborg,Doug Voet,Pei Lin,Scott Frazer,Petar Stojanov,Yingchun Liu,Lihua Zou,Jaegil Kim,Michael S. Lawrence,Lynda Chin,Alexei Protopopov,Xingzhi Song,Jianhua Zhang,Angeliki Pantazi,Angela Hadjipanayis,Eunjung Lee,Lovelace J. Luquette,Semin Lee,Michael Parfenov,Netty Santoso,Jonathan G. Seidman,Andrew Wei Xu,Raju Kucherlapati,Peter J. Park,Junehawk Lee,Steven A. Roberts,Leszek J. Klimczak,David C. Fargo,Martin Lang,Yoon-La Choi,June Koo Lee,Woong-Yang Park,Wenyi Wang,Yu Fan,Jaeil Ahn,Rehan Akbani,John N. Weinstein,David Haussler,Singer Ma,Amie Radenbaugh,Jingchun Zhul,Tara M. Lichtenberg,Erik Zmuda,Aaron D. Black,Benjamin Hanf,Nilsa C. Ramirez,Lisa Wise,Jay Bowen,Kristen M. Leraas,Tracy M. Hall,Julie M. Gastier-Foster,William G. Kaelin,Leigh B. Thorne,Lori Boice,Mei Huang,Cathy D. Vocke,James Peterson,Robert Worrell,Maria J. Merino,Bogdan Czerniak,Kenneth Aldape,Christopher G. Wood,Paul T. Spellman,Michael B. Atkins,John C. Cheville,R. Houston Thompson,Mark A. Jensen,Todd Pihl,Yunhu Wan,Brenda Ayala,Julien Baboud,Sudhakar Velaga,Jessica Walton,Jia Liu,Sudha Chudamani,Ye Wu,Margi Sheth,Kenna R. Mills Shaw,John A. Demchok,Tanja M. Davidsen,Liming Yang,Zhining Wang,Roy Tarnuzzer,Jiashan Zhang,Greg Eley,Ina Felau,Jean C. Zenklusen,Carolyn M. Hutter,Mark S. Guyer,Bradley A. Ozenberger,Heidi J. Sofia +225 more
TL;DR: Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutations.
Journal ArticleDOI
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Hamid Bolouri,Jason E. Farrar,Timothy J. Triche,Rhonda E. Ries,Emilia L. Lim,Todd A. Alonzo,Todd A. Alonzo,Yussanne Ma,Richard A. Moore,Andrew J. Mungall,Marco A. Marra,Jinghui Zhang,Xiaotu Ma,Yu Liu,Yanling Liu,Jaime M. Guidry Auvil,Tanja Davidsen,Patee Gesuwan,Leandro C. Hermida,Bodour Salhia,Stephen Capone,Giridharan Ramsingh,Christian M. Zwaan,Sanne Noort,Stephen R. Piccolo,Stephen R. Piccolo,E. Anders Kolb,Alan S. Gamis,Malcolm A. Smith,Daniela S. Gerhard,Soheil Meshinchi +30 more
TL;DR: The results highlight the need for and facilitate the development of age-tailored targeted therapies for the treatment of pediatric AML.
Journal ArticleDOI
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.
Ryan D. Morin,Ryan D. Morin,Karen Mungall,Erin Pleasance,Andrew J. Mungall,Rodrigo Goya,Ryan D. Huff,David W. Scott,Jiarui Ding,Andrew Roth,Readman Chiu,Richard Corbett,Fong Chun Chan,Maria Mendez-Lago,Diane L. Trinh,Diane L. Trinh,Madison Bolger-Munro,Greg Taylor,Alireza Hadj Khodabakhshi,Susana Ben-Neriah,Julia R. Pon,Barbara Meissner,Bruce Woolcock,Noushin Farnoud,Sanja Rogic,Emilia L. Lim,Nathalie A. Johnson,Sohrab P. Shah,Steven J.M. Jones,Steven J.M. Jones,Christian Steidl,Christian Steidl,Robert A. Holt,Robert A. Holt,Inanc Birol,Inanc Birol,Richard A. Moore,Joseph M. Connors,Randy D. Gascoyne,Randy D. Gascoyne,Marco A. Marra,Marco A. Marra +41 more
TL;DR: A whole-genome-sequencing-based perspective ofDLBCL mutational complexity is provided by characterizing 40 de novo DLBCL cases and 13 cell lines and combining these data with DNA copy number analysis and RNA-seq from an extended cohort of 96 cases, which uncovered new gene targets of recurrent somatic point mutations and genes that are targeted by focal somatic deletions in this disease.
Journal ArticleDOI
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition
Kevin Litchfield,Kevin Litchfield,James L. Reading,Clare Puttick,Krupa Thakkar,Krupa Thakkar,Christopher Abbosh,Robert B Bentham,Thomas B.K. Watkins,Rachel Rosenthal,Dhruva Biswas,Andrew Rowan,Emilia L. Lim,Maise Al Bakir,Virginia Turati,José Afonso Guerra-Assunção,Lucia Conde,Andrew Furness,Sunil Kumar Saini,Sine Reker Hadrup,Javier Herrero,Se-Hoon Lee,Se-Hoon Lee,Peter Van Loo,Tariq Enver,James Larkin,Matthew D. Hellmann,Samra Turajlic,Samra Turajlic,Sergio A. Quezada,Nicholas McGranahan,Charles Swanton,Charles Swanton +32 more
TL;DR: In this article, the authors collated whole-exome and transcriptomic data for >1,000 CPI-treated patients across seven tumor types, utilizing standardized bioinformatics workflows and clinical outcome criteria to validate multivariable predictors of CPI sensitization.