Daxi Sun

TL;DR: In the study of alternative or additional mechanisms of resistance operating during antiviral therapy, overexpression and amplification of the MRP4 gene correlated with ATP-dependent efflux of PMEA and azidothymidine monophosphate from cells and, thus, with resistance to these drugs.

TL;DR: The topotecan resistance of cells overexpressingMrp4 and the polarized expression of Mrp4 in the choroid plexus and brain capillary endothelial cells indicate that Mr p4 has a dual role in protecting the brain from cytotoxins and suggest that the therapeutic efficacy of central nervous system-directed drugs that are Mrp3 substrates may be improved by developing Mrp 4 inhibitors.

TL;DR: It is demonstrated that ABCB6 is uniquely located in the outer mitochondrial membrane and is required for mitochondrial porphyrin uptake and is challenging previous assumptions about the intracellular movement of porphyrs and the factors controlling haem biosynthesis.

TL;DR: These findings are the first to demonstrate the induction of endogenous MDR1 by mutant p53 and provide insight into the mechanism.

TL;DR: It is suggested that Mrp4 and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver in order to protect the liver from accumulation of hydrophobic bile acids.