L
Linda H. Shapiro
Researcher at University of Connecticut
Publications - 76
Citations - 6269
Linda H. Shapiro is an academic researcher from University of Connecticut. The author has contributed to research in topics: Angiogenesis & Inflammation. The author has an hindex of 35, co-authored 76 publications receiving 5842 citations. Previous affiliations of Linda H. Shapiro include University of Tennessee & University of Connecticut Health Center.
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Journal Article
Aminopeptidase N Is a Receptor for Tumor-homing Peptides and a Target for Inhibiting Angiogenesis
Renata Pasqualini,Erkki Koivunen,Renate Kain,Johanna Lahdenranta,Johanna Lahdenranta,Michiie Sakamoto,Michiie Sakamoto,Anette Stryhn,Richard A. Ashmun,Linda H. Shapiro,Wadih Arap,Erkki Ruoslahti +11 more
TL;DR: It is shown here that the receptor for the NGR peptides in tumor vasculature is aminopeptidase N (APN; also called CD13), and APN is involved in angiogenesis and can serve as a target for delivering drugs into tumors and for inhibitingAngiogenesis.
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Human aminopeptidase N is a receptor for human coronavirus 229E
C L Yeager,Richard A. Ashmun,Richard K. Williams,Christine B. Cardellichio,Linda H. Shapiro,A T Look,A T Look,Kathryn V. Holmes +7 more
TL;DR: It is reported that human aminopeptidase N, a cell-surface metalloprotease on intestinal, lung and kidney epithelial cells, is a receptor for human coronavirus strainHCV-229E, but not for HCV-OC43.
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Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.
TL;DR: In this article, the primary structure of CD13, a 150-kD cell surface glycoprotein originally identified on subsets of normal and malignant human myeloid cells, was determined using overlapping complementary DNA (cDNA) clones.
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CD13/APN is activated by angiogenic signals and is essential for capillary tube formation.
Shripad V. Bhagwat,Johanna Lahdenranta,Ricardo J. Giordano,Wadih Arap,Renata Pasqualini,Linda H. Shapiro +5 more
TL;DR: It is shown that endogenous CD13/APN levels in primary cells and cell lines are up-regulated in response to hypoxia, angiogenic growth factors, and signals regulating capillary tube formation during angiogenesis, establishing the CD13-APN metalloprotease as an important regulator of endothelial morphogenesis duringAngiogenesis.
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Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia
TL;DR: A t(17;19) chromosomal translocation in early B-lineage acute leukemia was shown to result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix transcription factor gene on chromosome 19, fused to sequences from a previously unidentified gene (HLF) on chromosome 17 that encodes a hepatic leukemia factor.