John Repass

TL;DR: Gain-of-function studies establish the integral role for NANOG in neoplastic processes and shed light on its mechanisms of action in tumorigenesis, as well as establishing the importance of CXCR4, IGFBP5, CD133 and ALDH1 in this work.

TL;DR: Two bacterial artificial chromosome transgenic mouse lines are generated in which IL‐7 regulatory elements drive expression of either Cre recombinase or a human CD25 (hCD25) cell surface reporter molecule and these transgenic lines provide novel genetic tools to identifyIL‐7 producing cells in various tissues and to manipulate gene expression selectively in IL‐ 7 expressing cells.

TL;DR: Findings suggest that enhanced growth factor (Akt/mTORC1 and STAT3) and inflammatory (NFκB and cytokines) signaling may play a role in dietary energy balance effects on prostate cancer progression in Hi-Myc mice.

TL;DR: It is suggested that differential expression of genes involved in inflammatory pathways in epidermis may play a key role in genetic differences in susceptibility to skin tumor promotion in DBA/2 and C57BL/6 mice.

TL;DR: In this paper, the authors used RNA-Seq and microRNA (miRNA) microarrays to better define the molecular features of BK5.ATF3-derived mammary tumors.