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Deborah Donnell
Researcher at Fred Hutchinson Cancer Research Center
Publications - 231
Citations - 13344
Deborah Donnell is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Pre-exposure prophylaxis & Population. The author has an hindex of 49, co-authored 199 publications receiving 11097 citations. Previous affiliations of Deborah Donnell include University of California, Los Angeles & University of Washington.
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HIV incidence among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: a randomised, multicentre, open-label trial
Khatija Ahmed,Jared M. Baeten,Mags Beksinska,Linda-Gail Bekker,Elizabeth A. Bukusi,Deborah Donnell,Peter Gichangi,Kate B. Heller,G Justus Hofmeyr,Jessica Justman,Margaret P Kasaro,James Kiarie,Cheryl Louw,Timothy D. Mastro,Charles S. Morrison,Nelly Mugo,Gonasagrie Nair,Kavita Nanda,Zelda Nhlabatsi,Maricianah Onono,Thesla Palanee-Phillips,Melanie Pleaner,Helen Rees,Mandisa Singata-Madliki,Caitlin W Scoville,Raesibe Agnes Pearl Selepe,Kathleen Shears,Sydney Sibiya,Jennifer A. Smit,Petrus S. Steyn,Jeffrey S. A. Stringer,Douglas Taylor,Katherine K. Thomas,Julia D Welch +33 more
TL;DR: A randomised, multicentre, open-label trial to compare DMPA-IM, a copper intrauterine device (IUD), and a levonorgestrel (LNG) implant among African women seeking effective contraception and living in areas of high HIV incidence.
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Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition
Lawrence Corey,Peter B. Gilbert,Michal Juraska,David C. Montefiori,Lynn Morris,Shelly Karuna,Srilatha Edupuganti,Nyaradzo Mgodi,Allan C. deCamp,Erika Rudnicki,Yunda Huang,Pedro Gonzales,Robinson Cabello,Catherine Orrell,Javier R. Lama,Fatima Laher,Erica Lazarus,Jorge Sanchez,Ian Frank,Juan C Hinojosa,Magdalena E. Sobieszczyk,Kyle E. Marshall,Pamela G Mukwekwerere,Joseph Makhema,Lindsey R. Baden,James I. Mullins,Carolyn Williamson,John Hural,M. Juliana McElrath,Carter Bentley,Simbarashe Takuva,Margarita M. Gomez Lorenzo,David N. Burns,Nicole Espy,April K. Randhawa,Nidhi Kochar,Estelle Piwowar-Manning,Deborah Donnell,Nirupama Sista,Philip Andrew,James G. Kublin,Glenda Gray,Julie E. Ledgerwood,John R. Mascola,Myron S. Cohen,Hvtn,Hptn,Hptn Study Teams +47 more
TL;DR: VRC01 did not prevent overall HIV-1 acquisition more effectively than placebo, but analyses of VRC01-sensitive HIV- 1 isolates provided proof-of-concept that bnAb prophylaxis can be effective.
Journal ArticleDOI
Adherence to Antiretroviral Prophylaxis for HIV Prevention: A Substudy Cohort within a Clinical Trial of Serodiscordant Couples in East Africa
Jessica E. Haberer,Jared M. Baeten,James D. Campbell,Jonathan Wangisi,Elly Katabira,Allan R. Ronald,Elioda Tumwesigye,Christina Psaros,Steven A. Safren,Norma C. Ware,Katherine K. Thomas,Deborah Donnell,Deborah Donnell,Meighan Krows,Lara Kidoguchi,Connie Celum,David R. Bangsberg,David R. Bangsberg +17 more
TL;DR: The association between high adherence to antiretroviral pre-exposure prophylaxis and HIV transmission in a substudy of serodiscordant couples participating in a clinical trial is investigated.
Journal ArticleDOI
Estimating the Impact of Plasma HIV-1 RNA Reductions on Heterosexual HIV-1 Transmission Risk
Jairam R. Lingappa,James P. Hughes,Richard S. Wang,Jared M. Baeten,Connie Celum,Glenda Gray,Wendy S. Stevens,Wendy S. Stevens,Deborah Donnell,Mary S. Campbell,Carey Farquhar,Myron Essex,James I. Mullins,Robert W. Coombs,Helen Rees,Lawrence Corey,Anna Wald,Hiv Transmission Study Team +17 more
TL;DR: This model is based on follow-up of 3381 HIV-1 serodiscordant couples over 5017 person-years encompassing 108 genetically-linked HIV- 1 transmission events and estimates that 90% of overall HIV-2 infections averted by a 0.74 copies/mL reduction could be achieved by targeting this reduction to the 58% of the cohort with plasma HIV-3 levels ≥4 log10 copies/ mL.
Journal ArticleDOI
Coreceptor Tropism in Human Immunodeficiency Virus Type 1 Subtype D: High Prevalence of CXCR4 Tropism and Heterogeneous Composition of Viral Populations
Wei Huang,Susan H. Eshleman,Jonathan Toma,Signe Fransen,Eric Stawiski,Ellen E. Paxinos,Jeannette M. Whitcomb,Alicia M. Young,Deborah Donnell,Francis Mmiro,Philippa Musoke,Laura A. Guay,J. Brooks Jackson,Neil Parkin,Christos J. Petropoulos +14 more
TL;DR: These observations have implications for pathogenesis and treatment of sub type D-infected individuals, for the association between V3 sequence and coreceptor tropism phenotype, and for understanding potential mechanisms of evolution from exclusive CCR5 use to efficient CXCR4 use by subtype D HIV-1.