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Deborah Luxenberg
Researcher at MedImmune
Publications - 26
Citations - 5197
Deborah Luxenberg is an academic researcher from MedImmune. The author has contributed to research in topics: Immune system & Antibody. The author has an hindex of 15, co-authored 26 publications receiving 4921 citations. Previous affiliations of Deborah Luxenberg include Genetics Institute, Inc..
Papers
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Journal ArticleDOI
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Spencer Liang,Xiang-Yang Tan,Deborah Luxenberg,Riyez Karim,Kyriaki Dunussi-Joannopoulos,Mary Collins,Lynette A. Fouser +6 more
TL;DR: IL-22 is identified as a new cytokine expressed by Th17 cells that synergizes with IL- 17A or IL-17F to regulate genes associated with skin innate immunity.
Journal ArticleDOI
Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells
Geoffrey L. Stephens,Rebecca S. McHugh,Matthew J. Whitters,Deborah A. Young,Deborah Luxenberg,Beatriz M. Carreno,Mary Collins,Ethan M. Shevach +7 more
TL;DR: GITR-L provides an important signal for CD25− T cells, rendering them resistant to CD25+-mediated regulation at the initiation of the immune response, and may enhance the susceptibility of effector T cells to suppressor activity during the course of an infectious insult.
Patent
Antibodies against PD-1
Mary Collins,Clive Wood,Beatriz M. Carreno,Deborah Luxenberg,Jason Jussif,Laura L. Carter,Frances Bennett,Viia Valge-Archer,John Andrews,Caroline Russell +9 more
TL;DR: In this article, the authors provided antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular.
Journal ArticleDOI
Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells
Jill F. Wright,Yongjing Guo,Amira Quazi,Deborah Luxenberg,Frann Bennett,John F. Ross,Yongchang Qiu,Matthew J. Whitters,Kathleen N. Tomkinson,Kyri Dunussi-Joannopoulos,Beatriz M. Carreno,Mary Collins,Neil M. Wolfman +12 more
TL;DR: The data suggest that the IL-17F/IL-17A heterodimer may contribute to the T cell-mediated immune responses.
Journal ArticleDOI
Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses.
Frann Bennett,Deborah Luxenberg,Vincent Ling,I-Ming Wang,Kim Marquette,David C. Lowe,Nighat Khan,Geertruida M. Veldman,Kenneth Jacobs,Viia Valge-Archer,Mary Collins,Beatriz M. Carreno +11 more
TL;DR: It is suggested that IL-7 and IL-15 restore proliferation under conditions of PD-1 engagement by enhancing high-affinity IL-2R expression and hence,IL-2 responsiveness, and thus, STAT5 has been implicated in the maintenance of IL- 2Rα expression.