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Xiang-Yang Tan
Researcher at Pfizer
Publications - 28
Citations - 3140
Xiang-Yang Tan is an academic researcher from Pfizer. The author has contributed to research in topics: Receptor & RAGE (receptor). The author has an hindex of 13, co-authored 27 publications receiving 2947 citations.
Papers
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Journal ArticleDOI
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Spencer Liang,Xiang-Yang Tan,Deborah Luxenberg,Riyez Karim,Kyriaki Dunussi-Joannopoulos,Mary Collins,Lynette A. Fouser +6 more
TL;DR: IL-22 is identified as a new cytokine expressed by Th17 cells that synergizes with IL- 17A or IL-17F to regulate genes associated with skin innate immunity.
Journal ArticleDOI
Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
Emily C Lutterloh,Steven M. Opal,Debra D. Pittman,James C. Keith,Xiang-Yang Tan,Brian M. Clancy,Helen Palmer,Kim Milarski,Ying Ying Sun,John E. Palardy,Nicholas A. Parejo,Noubar Kessimian +11 more
TL;DR: RAGE-/-, RAGE+/-, and anti-RAGE antibody-treated animals were resistant to lethality from Listeria monocytogenes by almost two orders of magnitude compared with wild-type mice and delayed treatment up to 24 hours after CLP resulted in a significant survival benefit compared with control mice.
Journal ArticleDOI
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.
Lisa A. Collins-Racie,Carl R. Flannery,Weilan Zeng,Christopher John Corcoran,Bethany Annis-Freeman,Michael J. Agostino,Maya Arai,Elizabeth DiBlasio-Smith,Andrew J. Dorner,Katy E. Georgiadis,Macy Jin,Xiang-Yang Tan,Elisabeth A. Morris,Edward R. Lavallie +13 more
TL;DR: The ability of ADAMTS-8 to exhibit 'aggrecanase' activity was examined and a neoepitope monoclonal antibody was developed and used to demonstrate the ability of the protein to cleave aggrecan at the aggrecaase-susceptible Glu373-Ala374 peptide bond.
Journal ArticleDOI
Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2.
Jing Li,Kathy Tomkinson,Xiang-Yang Tan,Paul W. Wu,Grace Yan,Vikki Spaulding,Bijia Deng,Bethany Annis-Freeman,Kathleen Heveron,Richard Zollner,Gerard De Zutter,Jill F. Wright,Tara K. Crawford,Wei Liu,Kenneth Jacobs,Neil M. Wolfman,Vincent Ling,Debra D. Pittman,Geertruida M. Veldman,Lynette A. Fouser +19 more
TL;DR: A temporal model for the development of a functional IL-22 cytokine-receptor-Fc complex is proposed, based on data studied, which indicates that the IL-10R2(ECD) binds to a surface created by the interaction between IL- 22 and the Il-22R(ECD), and thereby further stabilizes the association ofIL-22 within this cytokine/receptor complex.
Patent
Il-13 binding agents
Lioudmila Tchistiakova,Marion T. Kasaian,Debra D. Donaldson,Xiang-Yang Tan,Davinder Gill,Bruce A. Jacobson,Macy Jin,Samuel J. Goldman,Knopf John,Angela Widom +9 more
TL;DR: In this paper, agents (i.e., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL 13 to interact with IL-13 receptors and signaling mediators are disclosed.