D
Deeann Wallis
Researcher at University of Alabama at Birmingham
Publications - 44
Citations - 2937
Deeann Wallis is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Neurofibromin 1 & Attention deficit hyperactivity disorder. The author has an hindex of 22, co-authored 41 publications receiving 2654 citations. Previous affiliations of Deeann Wallis include Texas A&M Health Science Center & Texas A&M University.
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Journal ArticleDOI
Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly.
Deeann Wallis,Erich Roessler,Erich Roessler,Ute Hehr,Luisa Nanni,Tim Wiltshire,Antonio Richieri-Costa,Gabriele Gillessen-Kaesbach,Elaine H. Zackai,Johanna M. Rommens,Maximilian Muenke,Maximilian Muenke +11 more
TL;DR: It is proposed that SIX3 is the HPE2 gene, essential for the development of the anterior neural plate and eye in humans, and Mutational analysis has identified four different mutations in the homeodomain of Six3 that are predicted to interfere with transcriptional activation and are associated with HPE.
Journal ArticleDOI
Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation
TL;DR: It is demonstrated that Gfi1 functions downstream of Math1 in intestinal secretory lineage differentiation, and a model of intestinal cell fate choice in which beta-catenin and Cdx function upstream ofMath1, and lineage-specific genes such as Ngn3 act downstream of Gfi2 is proposed.
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Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing
Yanjia J. Zhang,Manchi C. M. Reddy,Thomas R. Ioerger,Alissa C. Rothchild,Véronique Dartois,Brian M. Schuster,Andrej Trauner,Deeann Wallis,Stacy Galaviz,Curtis Huttenhower,James C. Sacchettini,Samuel M. Behar,Eric J. Rubin +12 more
TL;DR: A genome-scale study of Mycobacterium tuberculosis is presented that uncovers the bacterial determinants of surviving host immunity, sets of genes the authors term "counteractomes", and identifies a small-molecule inhibitor of Mtb tryptophan synthesis, which converts Mtb into a tryPTophan auxotroph and restores the efficacy of a failed host defense.
Journal ArticleDOI
A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication
Mauricio Arcos-Burgos,Mahim Jain,Maria Teresa Acosta,Shively S,Horia Stanescu,Deeann Wallis,Sabina Domené,Jorge I. Vélez,Jayaprakash D. Karkera,Joan Z. Balog,Kate Berg,Robert Kleta,William A. Gahl,Erich Roessler,Robert Long,Lie J,David Pineda,Ana C. Londoño,Juan David Palacio,Andres Arbelaez,Francisco Lopera,Josephine Elia,Hakon Hakonarson,Stefan Johansson,Per M. Knappskog,Jan Haavik,Marta Ribasés,Bru Cormand,Mònica Bayés,Miguel Casas,Josep Antoni Ramos-Quiroga,A. Hervas,Brion S. Maher,Stephen V. Faraone,Christiane Seitz,Christine M. Freitag,Haukur Palmason,Jobst Meyer,Marcel Romanos,Susanne Walitza,U. Hemminger,Andreas Warnke,Jasmin Romanos,Tobias J. Renner,Christian Jacob,K.P. Lesch,James M. Swanson,Vortmeyer A,Joan E. Bailey-Wilson,Francisco X. Castellanos,Maximilian Muenke +50 more
TL;DR: Functional studies revealed that LPHN3 variants are expressed in key brain regions related to attention and activity, affect metabolism in neural circuits implicated in ADHD, and are associated with response to stimulant medication.
Journal ArticleDOI
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.
Deeann Wallis,Melanie J. Hamblen,Yi Zhou,Koen J. T. Venken,Armin Schumacher,H. Leighton Grimes,Huda Y. Zoghbi,Stuart H. Orkin,Hugo J. Bellen +8 more
TL;DR: Gfi1 is expressed in the developing nervous system, is required for inner ear hair cell differentiation, and its loss causes programmed cell death.