D
Deepti Putcha
Researcher at Harvard University
Publications - 28
Citations - 1536
Deepti Putcha is an academic researcher from Harvard University. The author has contributed to research in topics: Default mode network & Posterior cortical atrophy. The author has an hindex of 11, co-authored 22 publications receiving 1308 citations. Previous affiliations of Deepti Putcha include Brigham and Women's Hospital & Rhode Island Hospital.
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Journal ArticleDOI
Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
Alexander Drzezga,J. Alex Becker,Koene R. A. Van Dijk,Aishwarya Sreenivasan,Tanveer Talukdar,Caroline Sullivan,Aaron P. Schultz,Jorge Sepulcre,Deepti Putcha,Doug Greve,Keith A. Johnson,Keith A. Johnson,Reisa A. Sperling,Reisa A. Sperling +13 more
TL;DR: The results indicate that disruption of functional connectivity and hypometabolism may represent early functional consequences of emerging molecular Alzheimer's disease pathology, evolving prior to clinical onset of dementia.
Journal ArticleDOI
Amyloid-β Associated Cortical Thinning in Clinically Normal Elderly
J. Alex Becker,Trey Hedden,Jeremy Carmasin,Jacqueline E. Maye,Dorene M. Rentz,Dorene M. Rentz,Deepti Putcha,Bruce Fischl,Bruce Fischl,Douglas N. Greve,Gad A. Marshall,Gad A. Marshall,Stephen Salloway,Stephen Salloway,Donald Marks,Randy L. Buckner,Reisa A. Sperling,Reisa A. Sperling,Keith A. Johnson,Keith A. Johnson +19 more
TL;DR: Whether clinically normal older individuals with Aβ deposition revealed by positron emission tomography imaging using Pittsburgh Compound B also have evidence of both cortical thickness and hippocampal volume reductions in a pattern similar to that seen in AD is investigated.
Journal ArticleDOI
Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals.
Liang Wang,Peter S. LaViolette,Kelly O'Keefe,Deepti Putcha,Akram Bakkour,Koene R. A. Van Dijk,Maija Pihlajamäki,Bradford C. Dickerson,Reisa A. Sperling,Reisa A. Sperling +9 more
TL;DR: These findings provide support for the hypothesis that one of the functions of this large-scale brain network is to subserve episodic memory processes, and further confirmed the spatial specificity of the relationship between hippocampal-default network posteromedial cortical connectivity and memory performance in older subjects.
Journal ArticleDOI
Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults.
Deepti Putcha,Michael Brickhouse,Kelly O'Keefe,Caroline Sullivan,Dorene M. Rentz,Gad A. Marshall,Brad C. Dickerson,Reisa A. Sperling +7 more
TL;DR: The hypothesis that paradoxically increased hippocampal activity may be an early indicator of AD-related neurodegeneration in a distributed network of brain regions supporting memory and other cognitive domains is supported.
Journal ArticleDOI
Altered intrinsic functional coupling between core neurocognitive networks in Parkinson's disease.
TL;DR: It is demonstrated that individuals with PD have a dysfunctional pattern of interaction between core neurocognitive networks compared to what is found in healthy individuals, and that interaction between the SN and the striatum is even more profoundly disrupted in those with greater disease severity.