C
Carol Deegan
Researcher at Institute of Technology, Tallaght
Publications - 7
Citations - 553
Carol Deegan is an academic researcher from Institute of Technology, Tallaght. The author has contributed to research in topics: Crystal structure & Phenanthroline. The author has an hindex of 6, co-authored 7 publications receiving 509 citations.
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Journal ArticleDOI
Synthesis, X-ray crystal structures and biomimetic and anticancer activities of novel copper(II)benzoate complexes incorporating 2-(4'-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline as chelating nitrogen donor ligands.
Michael Devereux,Denis O Shea,Andrew Kellett,Andrew Kellett,Malachy McCann,Maureen Walsh,Denise A. Egan,Carol Deegan,Kinga Kędziora,Georgina M. Rosair,Helge Müller-Bunz +10 more
TL;DR: The catalase and superoxide dismutase (SOD) activities of the four complexes along with those of the known phenanthroline complexes were investigated and the structural results for 4 represent a re-examination of this crystallographically known compound for which no hydrogen atom coordinates have been previously reported.
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In vitro cancer chemotherapeutic activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)] · 2H2O, [Cu(phen)2(mal)] · 2H2O and [Mn(phen)2(mal)] · 2H2O (malH2 = malonic acid) using human cancer cells
TL;DR: The chemotherapeutic potential of 1,10-phenanthroline (phen), and three of its transition metal complexes was determined using two human carcinoma cell lines (A-498 and Hep-G2) as discussed by the authors.
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Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2(NH3)2(salH)2] (salH2= salicylic acid)
Barry Coyle,Malachy McCann,Kevin Kavanagh,Michael Devereux,Vickie McKee,Nijhuma Kayal,Denise A. Egan,Carol Deegan,Gregory J. Finn +8 more
TL;DR: SalH(2), [Ag(2)(NH(3))(2)(salH)(2)] and AgClO(4) produced a dose-dependent cytotoxic response against the three human derived cancer cell lines, Cal-27, Hep-G2 and A-498, with the Ag(I)-containing reagents being the most effective.
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In vitro anti-tumour effect of 1,10-phenanthroline-5,6-dione (phendione), [Cu(phendione)3](ClO4)2.4H2O and [Ag(phendione)2]ClO4 using human epithelial cell lines.
Carol Deegan,Barry Coyle,Barry Coyle,Malachy McCann,Malachy McCann,Michael Devereux,Michael Devereux,Denise A. Egan +7 more
TL;DR: Results suggest that phendione and its Cu(II) and Ag(I) complexes may be capable of acting as highly effective anti-cancer therapies, which with careful administration could provide very potent and effective alternatives to cisplatin.
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Synthesis, antimicrobial activity and chemotherapeutic potential of inorganic derivatives of 2-(4'-thiazolyl)benzimidazole[thiabendazole]: X-ray crystal structures of [Cu(TBZH)2Cl]Cl.H2O.EtOH and TBZH2NO3 (TBZH=thiabendazole).
Michael Devereux,Malachy McCann,Denis O Shea,Rachel Kelly,Denise A. Egan,Carol Deegan,Kevin Kavanagh,Vickie McKee,Gregory J. Finn +8 more
TL;DR: The dimethyl sulphoxide soluble complexes 3 and 4, along with metal free TBZH were assessed for their cancer chemotherapeutic potential towards two human epithelial-derived cancer model cell lines and showed similar dose-dependent cytotoxicity in both cell lines.