D
Dennis B. Lubahn
Researcher at University of Missouri
Publications - 201
Citations - 29869
Dennis B. Lubahn is an academic researcher from University of Missouri. The author has contributed to research in topics: Estrogen receptor & Estrogen receptor alpha. The author has an hindex of 79, co-authored 200 publications receiving 28809 citations. Previous affiliations of Dennis B. Lubahn include Mayo Clinic & University of Missouri System.
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Journal ArticleDOI
Functional characterization of naturally occurring mutant androgen receptors from subjects with complete androgen insensitivity
Terry R. Brown,Dennis B. Lubahn,Elizabeth M. Wilson,Frank S. French,Claude J. Migeon,Jeffry L. Corden +5 more
TL;DR: This study shows that some cases of CAIS are explained by an inability to form a functional AR-steroid complex and hence, the AR is unable to activate transcription of genes essential for male sex differentiation during fetal development.
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Transcription and Translation of Estrogen Receptor-β in the Male Reproductive Tract of Estrogen Receptor-α Knock-Out and Wild-Type Mice1
Cheryl S. Rosenfeld,Venkataseshu K. Ganjam,Julia A. Taylor,Xiaohui Yuan,James R. Stiehr,Matthew P. Hardy,Dennis B. Lubahn +6 more
TL;DR: Immunohistochemical localization with both N- and C-terminal anti-ERβ antibodies demonstrated that ERβ is present in the Leydig cells of the testes and in the epithelium of both the efferent ductules and the initial segment of the epididymis of ERα KO mice.
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Natural Killer Cells Express Estrogen Receptor-α and Estrogen Receptor-β and Can Respond to Estrogen Via a Non-Estrogen Receptor-α-Mediated Pathway
Edward M. Curran,Londa J. Berghaus,Nicholas J. Vernetti,Anthony J. Saporita,Dennis B. Lubahn,D. Mark Estes +5 more
TL;DR: Data suggest that ERβ or possibly a novel receptor is involved in mediating estrogen action onNK cell activity and raise the potential for therapeutic modulation of NK cell activity with selective estrogen receptor modulators (SERMS).
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Complete androgen insensitivity due to deletion of exon C of the androgen receptor gene highlights the functional importance of the second zinc finger of the androgen receptor in vivo.
Charmian A. Quigley,Bronwen A J Evans,Jorge A. Simental,Keith B. Marschke,Madhabananda Sar,Dennis B. Lubahn,Peter Davies,Ieuan A. Hughes,Elizabeth M. Wilson,Frank S. French +9 more
TL;DR: In a pair of siblings with complete androgen insensitivity who had supranormal levels of androgen binding in genital skin fibroblasts, polymerase chain reaction and Southern blot analysis of the androgen receptor gene revealed an in-frame deletion of exon C encoding the second zinc finger of the receptor.
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Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro.
Nader S. Shenouda,Christine Zhou,Jimmy D. Browning,Pete J Ansell,Mary S. Sakla,Dennis B. Lubahn,Ruth S. MacDonald +6 more
TL;DR: These 7 phytoestrogens, through different mechanisms, are effective inhibitors of prostate tumor cell growth and growth inhibition in androgen-insensitive human prostate tumor cells.