D
Devina Divekar
Researcher at University of East Anglia
Publications - 11
Citations - 1823
Devina Divekar is an academic researcher from University of East Anglia. The author has contributed to research in topics: ATG16L1 & Autophagy. The author has an hindex of 6, co-authored 11 publications receiving 1598 citations. Previous affiliations of Devina Divekar include University of Cambridge & Norwich Research Park.
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Journal ArticleDOI
Foxp3+ follicular regulatory T cells control the germinal center response
Michelle A. Linterman,Wim Pierson,Sau K. Lee,Axel Kallies,Shimpei Kawamoto,Tim F. Rayner,Monika Srivastava,Devina Divekar,Laura L. Beaton,Jennifer J. Hogan,Sidonia Fagarasan,Adrian Liston,Kenneth G. C. Smith,Carola G. Vinuesa +13 more
TL;DR: A population of Foxp3+Blimp-1+CD4+ T cells constituting 10–25% of the CXCR5highPD-1highCD4- T cells found in the germinal center after immunization with protein antigens are described.
Journal Article
Foxp3( ) follicular regulatory T cells control T follicular helper cells and the germinal centre response
Michelle A. Linterman,Wim Pierson,Sau K. Lee,Axel Kallies,Shimpei Kawamoto,Tim F. Rayner,Monika Srivastava,Devina Divekar,Laura L. Beaton,Jennifer J. Hogan,Sidonia Fagarasan,Adrian Liston,Carola G. Vinuesa,K. C. G Smith +13 more
Journal ArticleDOI
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection
Michelle A. Linterman,Alice E. Denton,Devina Divekar,Ilona Zvetkova,Leanne Kane,Cristina Ferreira,Marc Veldhoen,Simon Clare,Gordon Dougan,Marion Espéli,Kenneth G. C. Smith +10 more
TL;DR: It is demonstrated that CD28 persistence is required for helper T cell polarization in response to infection, describing a novel function for CD28 that is distinct from its role in T cell priming.
Journal ArticleDOI
The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis.
Shashank Rai,Maryam Arasteh,Matthew Jefferson,Timothy Pearson,Yingxue Wang,Weijiao Zhang,Bertalan Bicsak,Devina Divekar,Penny P. Powell,Ronald Naumann,Naiara Beraza,Simon R. Carding,Oliver Florey,Ulrike Mayer,Thomas Wileman +14 more
TL;DR: It is suggested that autophagy maintains tissue homeostasis in mice independently of LC3-associated phagocytosis, and interactions between WIPI2 and ATG16L1 were less critical for Autophagy in the brain, which may allow a low level of autophile to overcome neonatal lethality.
Journal ArticleDOI
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection.
Jayna J Mistry,Christopher R. Marlein,Jamie A Moore,Charlotte Hellmich,Charlotte Hellmich,Edyta E. Wojtowicz,James G W Smith,Iain C. Macaulay,Yu Sun,Adam Morfakis,Angela M. Patterson,Rebecca H Horton,Devina Divekar,Christopher J. Morris,Anna Haestier,Federica Di Palma,Naiara Beraza,Kristian M. Bowles,Kristian M. Bowles,Stuart A. Rushworth +19 more
TL;DR: This discovery demonstrates that mitochondrial transfer from the bone marrow microenvironment to HSCs is an early physiologic event in the mammalian response to acute bacterial infection and results in bioenergetic changes which underpin emergency granulopoiesis.