D
Devon M. Chenette
Researcher at New York University
Publications - 11
Citations - 365
Devon M. Chenette is an academic researcher from New York University. The author has contributed to research in topics: Myocyte & Regeneration (biology). The author has an hindex of 7, co-authored 11 publications receiving 246 citations. Previous affiliations of Devon M. Chenette include Yale University.
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Journal ArticleDOI
mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy
Kara N. Goldman,Devon M. Chenette,Rezina Arju,Francesca E. Duncan,David L. Keefe,Jamie Grifo,Robert J. Schneider +6 more
TL;DR: It is shown that mTOR inhibition preserves the ovarian reserve, primordial follicle counts, serum anti-Mullerian hormone levels, and fertility, indicating a potentially effective and readily accessible pharmacologic approach to fertility preservation during conventional chemotherapy.
Journal ArticleDOI
Physiological networks and disease functions of RNA-binding protein AUF1.
TL;DR: AUF1 has been implicated in controlling a variety of physiological functions through its ability to regulate the expression of numerous mRNAs containing 3′‐UTR AREs, thereby coordinating functionally related pathways.
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Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration
Yuichi Sekine,Alexander T. Lin-Moore,Devon M. Chenette,Xingxing Wang,Zhaoxin Jiang,William B. J. Cafferty,Marc Hammarlund,Stephen M. Strittmatter +7 more
TL;DR: A comprehensive functional screen reveals multiple pathways restricting axonal regeneration and neurological recovery after injury and validates a cell-autonomous restriction of regeneration by Rab27.
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RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels.
Amaresh C. Panda,Kotb Abdelmohsen,Je-Hyun Yoon,Jennifer L. Martindale,Xiaoling Yang,Jessica Curtis,Evi M. Mercken,Devon M. Chenette,Yongqing Zhang,Robert J. Schneider,Kevin G. Becker,Rafael de Cabo,Myriam Gorospe +12 more
TL;DR: Investigating the function of AUF1 in skeletal muscle differentiation found that it associated with the 3′ untranslated region (UTR) of Mef2c mRNA and promoted MEF2C translation without affecting Mef 2c mRNA stability, and proposed that MEf2C is a key effector of the myogenesis program promoted by AUF 1.
Journal ArticleDOI
Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity
Devon M. Chenette,Adam B. Cadwallader,Tiffany L. Antwine,Lauren C. Larkin,Jinhua Wang,Bradley B. Olwin,Robert J. Schneider +6 more
TL;DR: Control of ARE-mRNAs containing 3' AU-rich elements by AUF1 represents a mechanism for adult stem cell regulation and is implicated in human skeletal muscle wasting diseases.