Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity
Devon M. Chenette,Adam B. Cadwallader,Tiffany L. Antwine,Lauren C. Larkin,Jinhua Wang,Bradley B. Olwin,Robert J. Schneider +6 more
TLDR
Control of ARE-mRNAs containing 3' AU-rich elements by AUF1 represents a mechanism for adult stem cell regulation and is implicated in human skeletal muscle wasting diseases.About:
This article is published in Cell Reports.The article was published on 2016-08-02 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Skeletal muscle & Myocyte.read more
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Mesenchymal stromal cell therapy for liver diseases
Mohammed Alfaifi,Mohammed Alfaifi,Young Woo Eom,Philip N. Newsome,Philip N. Newsome,Soon Koo Baik +5 more
TL;DR: The safety, efficacy, potential transplantation routes and therapeutic effects of MSCs in patients with liver fibrosis are summarized and some of the key strategies to enhance the functionality of M SCs are discussed, which include sorting and/or priming with factors such as cytokines, as well as genetic engineering.
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Control of satellite cell function in muscle regeneration and its disruption in ageing.
TL;DR: The role and regulation of satellite cells in skeletal muscle homeostasis and regeneration is discussed in this paper, highlighting the cell-intrinsic control of quiescence versus activation, the importance of satellite cell-niche communication, and deregulation of these mechanisms associated with ageing.
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The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis.
TL;DR: An integrated model is presented that depicts how a broad-ranging network of pathogenic events can arise from declining levels of functional hnRNPs that are inadequately compensated for by autoregulatory means.
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Fusion-Independent Satellite Cell Communication to Muscle Fibers During Load-Induced Hypertrophy.
Kevin A. Murach,Ivan J. Vechetti,Douglas W. Van Pelt,Samuel E. Crow,Cory M. Dungan,Vandré C Figueiredo,Kate Kosmac,Xu Fu,Christopher I. Richards,Christopher S. Fry,John J. McCarthy,Charlotte A. Peterson +11 more
TL;DR: Evidence is provided for satellite cell communication to muscle fibers during hypertrophy and how EV delivery from satellite cells can directly contribute to mechanical load-induced muscle fiberhypertrophy, independent of cell fusion to the fiber.
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Sema4D/PlexinB1 inhibition ameliorates blood-brain barrier damage and improves outcome after stroke in rats.
TL;DR: Evidence is provided that Sema4D disrupts BBB integrity and promotes an inflammatory response by binding to PlexinB1 in pericytes after transient middle cerebral artery occlusion and ameliorates blood‐brain barrier damage and improves outcome after stroke in rats.
References
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Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche.
Charlotte A. Collins,Charlotte A. Collins,Irwin Olsen,Peter S. Zammit,Louise Heslop,Aviva Petrie,Terence A. Partridge,Jennifer E. Morgan +7 more
TL;DR: Within a normally stable tissue, the satellite cell exhibits archetypal stem cell properties and is competent to form the basal origin of adult muscle regeneration.
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The highways and byways of mRNA decay.
TL;DR: Some of the mechanisms that are used by the cell to mediate and regulate this intriguing process of mRNA decay are discussed.
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Asymmetric Self-Renewal and Commitment of Satellite Stem Cells in Muscle
TL;DR: It is concluded that satellite cells are a heterogeneous population composed of stem cells and committed progenitors, and this work provides critical insights into satellite cell biology and open new avenues for therapeutic treatment of neuromuscular diseases.
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Direct isolation of satellite cells for skeletal muscle regeneration.
Didier Montarras,Jennifer E. Morgan,Charlotte A. Collins,Frédéric Relaix,Stéphane Zaffran,Ana Cumano,Terence A. Partridge,Margaret Buckingham +7 more
TL;DR: A Pax3GFP/+ mouse line is used to directly isolate (Pax3)(green fluorescent protein)–expressing muscle satellite cells, by flow cytometry from adult skeletal muscles, as a homogeneous population of small, nongranular, Pax7+, CD34+, CD45–, Sca1– cells.
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Single-Cell Analysis of Regulatory Gene Expression in Quiescent and Activated Mouse Skeletal Muscle Satellite Cells
TL;DR: C-met receptor is present beneath the basal lamina on presumptive satellite cells in intact muscle and that c-met mRNA and protein are expressed by all myofiber-associated satellite cells from the time of explant through the course of activation, proliferation, and differentiation.