J
Jessica Curtis
Researcher at National Institutes of Health
Publications - 15
Citations - 1030
Jessica Curtis is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Protein Carbonylation & Mitochondrion. The author has an hindex of 11, co-authored 15 publications receiving 875 citations. Previous affiliations of Jessica Curtis include University of Glasgow & Boston Children's Hospital.
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Journal ArticleDOI
Identifying polyglutamine protein species in situ that best predict neurodegeneration
Jason Miller,Montserrat Arrasate,Elizabeth Brooks,Clare Peters Libeu,Justin Legleiter,Danny M. Hatters,Jessica Curtis,Kenneth Cheung,Preethi Krishnan,Siddhartha Mitra,Kartika Widjaja,Benjamin A Shaby,Gregor P. Lotz,Yvonne M. Newhouse,Emily J Mitchell,Alexander P. Osmand,Michelle Gray,Vanitha Thulasiramin,Frédéric Saudou,Frédéric Saudou,Mark R. Segal,X. William Yang,Eliezer Masliah,Leslie M. Thompson,Paul J. Muchowski,Karl H. Weisgraber,Steven Finkbeiner +26 more
TL;DR: The results suggest that protein monomers and possibly small oligomers containing expanded polyQ stretches can adopt a conformation that is recognized by 3B5H10 and is toxic or closely related to a toxic species.
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Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.
Jessica Curtis,Paul A. Grimsrud,Wendy Wright,Xin Xu,Rocio Foncea,David W. Graham,Jonathan R. Brestoff,Brian M. Wiczer,Olga Ilkayeva,Katherine Cianflone,Deborah E. Muoio,Edgar A. Arriaga,David A. Bernlohr +12 more
TL;DR: Results indicate that downregulation of GSTA4 in adipose tissue leads to increased protein carbonylation, ROS production, and mitochondrial dysfunction and may contribute to the development of insulin resistance and type 2 diabetes.
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HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP
Ji Heon Noh,Kyoung Mi Kim,Kotb Abdelmohsen,Je-Hyun Yoon,Amaresh C. Panda,Rachel Munk,Jiyoung Kim,Jessica Curtis,Christopher A. Moad,Christina M. Wohler,Fred E. Indig,Wilson B. M. de Paula,Dawood B. Dudekula,Supriyo De,Yulan Piao,Xiaoling Yang,Jennifer L. Martindale,Rafael de Cabo,Myriam Gorospe +18 more
TL;DR: These findings indicate that RBPs HuR and GRSF1 govern the cytoplasmic and mitochondrial localization of the lncRNA RMRP, which is encoded by nuclear DNA but has key functions in mitochondria.
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Sending signals from the synapse to the nucleus: possible roles for CaMK, Ras/ERK, and SAPK pathways in the regulation of synaptic plasticity and neuronal growth.
TL;DR: Three signal transduction pathways are discussed: the Ca2+/calmodulin‐dependent kinase (CaMK) pathway, the Ras/ERK pathway, and the SAPK pathways that might function to couple synaptic activity to long‐term adaptive responses, in part through the regulation of new gene expression.
Journal ArticleDOI
Protein carbonylation and metabolic control systems
Jessica Curtis,Wendy S. Hahn,Eric K. Long,Joel S. Burrill,Edgar A. Arriaga,David A. Bernlohr +5 more
TL;DR: Reactive lipid aldehydes and their derivatives are detoxified via a variety of phase I and phase II systems, and when antioxidant defenses are compromised or oxidative conditions are increased, protein carbonylation is increased.