D
Dhanwanthie Ramduth
Researcher at University of KwaZulu-Natal
Publications - 4
Citations - 1205
Dhanwanthie Ramduth is an academic researcher from University of KwaZulu-Natal. The author has contributed to research in topics: Human leukocyte antigen & Viral load. The author has an hindex of 4, co-authored 4 publications receiving 1150 citations. Previous affiliations of Dhanwanthie Ramduth include Duke University.
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Journal ArticleDOI
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
Photini Kiepiela,Kholiswa C. Ngumbela,Christina F. Thobakgale,Dhanwanthie Ramduth,Isobella Honeyborne,Eshia Moodley,Shabashini Reddy,Chantal de Pierres,Zenele Mncube,Nompumelelo Mkhwanazi,Karen S. Bishop,Mary van der Stok,Kriebashnie Nair,Nasreen Khan,Hayley Crawford,Rebecca Payne,Alasdair Leslie,Julia G. Prado,Andrew J. Prendergast,John Frater,Noel D. McCarthy,Christian Brander,Gerald H. Learn,David C. Nickle,Christine Rousseau,Hoosen M. Coovadia,James I. Mullins,David Heckerman,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +32 more
TL;DR: A comprehensive analysis of the 160 dominant CD8+ T-cell responses in 578 untreated HIV-infected individuals from KwaZulu-Natal, South Africa suggested the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection.
Journal ArticleDOI
Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
Kholiswa C. Ngumbela,Cheryl L. Day,Zenele Mncube,Kriebashnie Nair,Dhanwanthie Ramduth,Christina F. Thobakgale,Eshia Moodley,Sharon Reddy,C. de Pierres,Nompumelelo Mkhwanazi,Karen S. Bishop,M van der Stok,Nasreen Ismail,Isobella Honeyborne,Hayley Crawford,Daniel G. Kavanagh,Christine Rousseau,David C. Nickle,James I. Mullins,David Heckerman,Bette T. Korber,Hoosen M. Coovadia,Photini Kiepiela,Philip J. R. Goulder,Bruce D. Walker +24 more
TL;DR: Experimental evidence is provided that not all epitope-specific responses contribute to immune containment, and that selective targeting of Env through HLA-B*5802 is at least ineffectual if not actively adverse in the containment of viremia.
Journal ArticleDOI
Human Immunodeficiency Virus-Specific CD8+ T-Cell Activity Is Detectable from Birth in the Majority of In Utero-Infected Infants
Christina F. Thobakgale,Dhanwanthie Ramduth,Sharon Reddy,Nompumelelo Mkhwanazi,Chantal de Pierres,Eshia Moodley,Wendy Mphatswe,Natasha Blanckenberg,Ayanda Cengimbo,Andrew J. Prendergast,Gareth Tudor-Williams,Krista L. Dong,Prakash Jeena,Gupreet Kindra,Raziya Bobat,Hoosen M. Coovadia,Photini Kiepiela,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +21 more
TL;DR: The data indicate that failure to control HIV replication in in utero-infected infants is not due to an inability to induce responses but instead suggest secondary failure of adaptive immunity in containing this infection.
Journal ArticleDOI
Motif Inference Reveals Optimal CTL Epitopes Presented by HLA Class I Alleles Highly Prevalent in Southern Africa
Isobella Honeyborne,Almas Rathod,Rico Buchli,Dhanwanthie Ramduth,Eshia Moodley,Prinisha Rathnavalu,Senica Chetty,Cheryl L. Day,Christian Brander,William H. Hildebrand,Bruce D. Walker,Bruce D. Walker,Photini Kiepiela,Philip J. R. Goulder +13 more
TL;DR: The studies set out to define, in a South African Zulu/Xhosa population at the epicenter of the epidemic, the epitopes presented by alleles highly prevalent, but for which the peptide-binding motif had not been characterized, and to facilitate optimization of epitopes in certain instances where conflicting reports in the literature exist regarding the peptides involved.