C
Christina F. Thobakgale
Researcher at University of KwaZulu-Natal
Publications - 30
Citations - 3542
Christina F. Thobakgale is an academic researcher from University of KwaZulu-Natal. The author has contributed to research in topics: Viral load & Human leukocyte antigen. The author has an hindex of 18, co-authored 28 publications receiving 3349 citations. Previous affiliations of Christina F. Thobakgale include Massachusetts Institute of Technology & Duke University.
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Journal ArticleDOI
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
Photini Kiepiela,Kholiswa C. Ngumbela,Christina F. Thobakgale,Dhanwanthie Ramduth,Isobella Honeyborne,Eshia Moodley,Shabashini Reddy,Chantal de Pierres,Zenele Mncube,Nompumelelo Mkhwanazi,Karen S. Bishop,Mary van der Stok,Kriebashnie Nair,Nasreen Khan,Hayley Crawford,Rebecca Payne,Alasdair Leslie,Julia G. Prado,Andrew J. Prendergast,John Frater,Noel D. McCarthy,Christian Brander,Gerald H. Learn,David C. Nickle,Christine Rousseau,Hoosen M. Coovadia,James I. Mullins,David Heckerman,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +32 more
TL;DR: A comprehensive analysis of the 160 dominant CD8+ T-cell responses in 578 untreated HIV-infected individuals from KwaZulu-Natal, South Africa suggested the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection.
Journal ArticleDOI
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Photini Kiepiela,Alasdair Leslie,Isobella Honeyborne,Danni Ramduth,Christina F. Thobakgale,Senica Chetty,Prinisha Rathnavalu,Corey Moore,Katja Pfafferott,Louise Hilton,Peter Zimbwa,Sarah Moore,Todd M. Allen,Christian Brander,Marylyn M. Addo,Marcus Altfeld,Ian James,Simon Mallal,Michael Bunce,Linda Barber,James J. Szinger,James J. Szinger,Cheryl L. Day,Paul Klenerman,James I. Mullins,Bette T. Korber,Bette T. Korber,Hoosen M. Coovadia,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +32 more
TL;DR: Analysis of class I restricted CD8+ T-cell responses against human immunodeficiency virus (HIV-1) indicates that the principal focus of HIV-specific activity is at the HLA-B locus, consistent with the observation that B alleles evolve more rapidly than A alleles.
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Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1
Javier Martinez-Picado,Julia G. Prado,Elizabeth E. Fry,Katja Pfafferott,Alasdair Leslie,Senica Chetty,Christina F. Thobakgale,Isobel Honeyborne,Hayley Crawford,Philippa C Matthews,Tilly Pillay,Christine Rousseau,James I. Mullins,Christian Brander,Bruce D. Walker,David I. Stuart,Photini Kiepiela,Philip J. R. Goulder +17 more
TL;DR: Analysis of HIV type 1 gag in 206 B*57/5801-positive subjects reveals three principle alternative TW10-associated variants, and each is strongly linked to concomitant additional variants within p24 Gag, suggesting that functional constraints operate against their occurrence alone.
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Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
Alasdair Leslie,Daniel G. Kavanagh,Isobella Honeyborne,Katja Pfafferott,Charles T. T. Edwards,Tilly Pillay,Louise Hilton,Christina F. Thobakgale,Danni Ramduth,Rika Draenert,Sylvie Le Gall,Graz Luzzi,Anne Edwards,Christian Brander,Andrew K. Sewell,Sarah Moore,James I. Mullins,Corey Moore,Simon Mallal,Nina Bhardwaj,Karina Yusim,Rodney E. Phillips,Paul Klenerman,Bette T. Korber,Photini Kiepiela,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder,Philip J. R. Goulder +29 more
TL;DR: The current studies, focusing on two examples of “negatively associated” or apparently preserved epitopes, suggest an explanation for this phenomenon: negative associations can arise as a result of positive selection of an escape mutation that accumulates in the population to the point at which it defines the consensus sequence.
Journal ArticleDOI
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection
Maximilian Muenchhoff,Emily Adland,Owen. Karimanzira,Carol Crowther,M Pace,Anna Csala,Ellen M. Leitman,Angeline Moonsamy,Callum McGregor,Callum McGregor,Jacob Hurst,Andreas Groll,Masahiko Mori,Smruti V. Sinmyee,Christina F. Thobakgale,Gareth Tudor-Williams,Andrew J. Prendergast,Henrik N. Kløverpris,Henrik N. Kløverpris,Julia Roider,Julia Roider,Alasdair Leslie,Delane Shingadia,Thea Brits,Samantha Daniels,John Frater,Christian B. Willberg,Bruce D. Walker,Bruce D. Walker,Thumbi Ndung'u,Pieter Jooste,Penny L. Moore,Penny L. Moore,Penny L. Moore,Lynn Morris,Lynn Morris,Lynn Morris,Philip J. R. Goulder,Philip J. R. Goulder,Philip J. R. Goulder +39 more
TL;DR: Investigating pediatric infection, where AIDS typically develops more rapidly than in adults, found low immune activation levels were low despite high viremia, suggesting closer similarities with nonpathogenetic mechanisms evolved over thousands of years in natural SIV hosts than those operating in HIV-infected adults.