H
Hayley Crawford
Researcher at University of Oxford
Publications - 20
Citations - 4134
Hayley Crawford is an academic researcher from University of Oxford. The author has contributed to research in topics: Epitope & Human leukocyte antigen. The author has an hindex of 18, co-authored 20 publications receiving 3659 citations.
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Journal ArticleDOI
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
Photini Kiepiela,Kholiswa C. Ngumbela,Christina F. Thobakgale,Dhanwanthie Ramduth,Isobella Honeyborne,Eshia Moodley,Shabashini Reddy,Chantal de Pierres,Zenele Mncube,Nompumelelo Mkhwanazi,Karen S. Bishop,Mary van der Stok,Kriebashnie Nair,Nasreen Khan,Hayley Crawford,Rebecca Payne,Alasdair Leslie,Julia G. Prado,Andrew J. Prendergast,John Frater,Noel D. McCarthy,Christian Brander,Gerald H. Learn,David C. Nickle,Christine Rousseau,Hoosen M. Coovadia,James I. Mullins,David Heckerman,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +32 more
TL;DR: A comprehensive analysis of the 160 dominant CD8+ T-cell responses in 578 untreated HIV-infected individuals from KwaZulu-Natal, South Africa suggested the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection.
Journal ArticleDOI
COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study.
Victoria Hall,Victoria Hall,Sarah Foulkes,Ayoub Saei,Nick Andrews,Nick Andrews,Blanche Oguti,Blanche Oguti,Andre Charlett,Andre Charlett,Andre Charlett,Edgar Wellington,Julia Stowe,Natalie Gillson,Ana Atti,Jasmin Islam,Ioannis Karagiannis,Katie Munro,Jameel Khawam,Meera Chand,Colin S Brown,Mary Ramsay,Mary Ramsay,Jamie Lopez-Bernal,Susan Hopkins,Susan Hopkins,N Andrews,A Atti,H Aziz,Tim Brooks,CS Brown,D Camero,C Carr,MA Chand,A Charlett,Hayley Crawford,Michael J. Cole,J Conneely,Silvia D'Arcangelo,Joanna Ellis,S Evans,S Foulkes,N Gillson,Robin Gopal,L Hall,V J Hall,P Harrington,Susan R. Hopkins,Jacqueline Hewson,Katja Hoschler,D Ironmonger,J Islam,Meaghan Kall,I Karagiannis,O Kay,J Khawam,E King,Peter Kirwan,R Kyffin,Angie Lackenby,M Lattimore,Ezra Linley,J Lopez-Bernal,L Mabey,Reuben McGregor,Shahjahan Miah,Ejm Monk,K Munro,Z Naheed,A Nissr,A M O'Connell,B Oguti,Henrietta U. Okafor,S Organ,J Osbourne,Ashley Otter,Minal Patel,Steven Platt,D Pople,K Potts,M Ramsay,Julie V. Robotham,Sakib Rokadiya,Cathy Rowe,A Saei,G Sebbage,Amanda Semper,Madhumita Shrotri,Ruth Simmons,Alex Soriano,P Staves,S Taylor,Arthur Taylor,A Tengbe,S Tonge,Amoolya Vusirikala,Sarah Wallace,E Wellington,Maria Zambon,D Corrigan,M Sartaj,L Cromey,Sharon Campbell,K Braithwaite,L Price,L Haahr,S Stewart,ED Lacey,Linda Partridge,Gretchen A Stevens,Y Ellis,H Hodgson,C Norman,B Larru,S Mcwilliam,A Roynon,J Northfield,Stephen Winchester,P Cieciwa,Aditi Pai,P Bakker,C Loughrey,A Watt,F Adair,Adrian Hawkins,Alastair Grant,R Temple-Purcell,J Howard,N Slawson,C Subudhi,Shân Davies,A Bexley,R Penn,N Wong,G Boyd,A Rajgopal,A Arenas-Pinto,R Matthews,A Whileman,R Laugharne,J Ledger,Trevor J. Barnes,Chris Jones,N Osuji,N Chitalia,T Bailey,S Akhtar,G Harrison,S Horne,Naomi F. Walker,Ken Agwuh,V Maxwell,J Graves,Stephen R. Williams,A O'Kelly,P Ridley,A Cowley,H Johnstone,P Swift,Jane Democratis,Manjula Meda,S Brake,J Gunn,A Selassi,S Hams,V Irvine,Badrinathan Chandrasekaran,C Forsyth,J Radmore,C Thomas,Kevin K. Brown,Stuart K. Roberts,P Burns,K Gajee,T Lewis,T M Byrne,F Sanderson,Stephen R Knight,Emily MacNaughton,Bjl Burton,Helen V. Smith,R Chaudhuri,J Aeron-Thomas,K Hollinshead,R.J. Shorten,A Swan,C Favager,J Murira,S Baillon,S Hamer,Aarti Shah,J Russell,D Brennan,A Dave,Ajay Chawla,F Westwell,D Adeboyeku,Padmasayee Papineni,C Pegg,Martin S. Williams,Shazaad Ahmad,Alex Horsley,Christian Gabriel,K Pagget,G Maloney,J Ashcroft,I Del Rosario,R Crosby-Nwaobi,D Flanagan,D Dhasmana,Stephen J. Fowler,E Cameron,L Prentice,C Sinclair,V Bateman,K McLelland-Brooks,A Ho,Michael P. Murphy,A Cochrane,A Gibson,K. Black,K Tempeton,Stacey Donaldson,L Coke,N Elumogo,J Elliott,Debra Padgett,A Cross,Mariyam Mirfenderesky,S Joyce,I Sinanovic,M Howard,P Cowling,M Brazil,E Hanna,A Abdelrazik,S Brand,EA Sheridan,B Wadams,A Lloyd,J Mouland,J Giles,G Pottinger,H Coles,Mark Joseph,M Lee,S Orr,H Chenoweth,D Browne,Cressida Auckland,R Lear,Tabitha Mahungu,Alison Rodger,Simon Warren,D Brooking,S Pai,R Druyeh,Edward M. Smith,S. Stone,Sarah Meisner,D Delgado,E Underhill,L Keen,M Aga,P Domingos,S Gormley,Caroline Kerrison,S Birch,T DeSilva,L Allsop,S Ambalkar,M Beekes,S Jose,J Tomlinson,Sharen Painter,Claire Price,Justin Pepperell,Keith D. James,T Trinick,L Moore,Jeremy N. Day,A Boulos,I Knox,E Defever,D McCracken,K Gray,A Houston,Tim Planche,R Pritchard Jones,Diane Wycherley,Sara Bennett,J Marrs,K Nimako,Benjamin J. Stewart,SC Bain,N Kalakonda,S Khanduri,A Ashby,Matthew T. G. Holden,N Mahabir,J Harwood,Brendan A I Payne,K Court,Nicholas J. White,R Longfellow,L E Hughes,M E Green,M Halkes,P Mercer,A Roebuck,Eleri Wilson-Davies,L Gallego,Rajeka Lazarus,N Aldridge,Louise Berry,Frances L. Game,Timothy M Reynolds,Christopher W Holmes,Martin Wiselka,A Higham,M Booth,C Duff,J Alderton,D Hilton,J Powell,Alan Jackson,AJ Plant,Nada Ahmed,T Chin,M Z Qazzafi,A M Moody,Robert Tilley,T Donaghy,M O'Kane,K Shipman,R Sierra,Chetan Parmar,Gordon B. Mills,Daniel Harvey,Ywj Huang,J Birch,Louise Robinson,S Board,A Broadley,C Laven,N Todd,David W Eyre,Katie Jeffery,Susanna Dunachie,Christopher J A Duncan,Paul Klenerman,Lance Turtle,Helen Baxendale,Jonathan L. Heeney +353 more
TL;DR: The SIREN study as discussed by the authors showed that the BNT162b2 vaccine can prevent both symptomatic and asymptomatic infection in working-age adults in the UK.
Journal ArticleDOI
Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1
Javier Martinez-Picado,Julia G. Prado,Elizabeth E. Fry,Katja Pfafferott,Alasdair Leslie,Senica Chetty,Christina F. Thobakgale,Isobel Honeyborne,Hayley Crawford,Philippa C Matthews,Tilly Pillay,Christine Rousseau,James I. Mullins,Christian Brander,Bruce D. Walker,David I. Stuart,Photini Kiepiela,Philip J. R. Goulder +17 more
TL;DR: Analysis of HIV type 1 gag in 206 B*57/5801-positive subjects reveals three principle alternative TW10-associated variants, and each is strongly linked to concomitant additional variants within p24 Gag, suggesting that functional constraints operate against their occurrence alone.
Journal ArticleDOI
Adaptation of HIV-1 to human leukocyte antigen class I
Yuka Kawashima,Katja Pfafferott,John Frater,Philippa C Matthews,Rebecca Payne,Marylyn M. Addo,Hiroyuki Gatanaga,Mamoru Fujiwara,Atsuko Hachiya,Hirokazu Koizumi,Nozomi Kuse,Shinichi Oka,Anna Duda,Andrew J. Prendergast,Hayley Crawford,Alasdair Leslie,Zabrina L. Brumme,Chanson J. Brumme,Todd M. Allen,Christian Brander,Christian Brander,Richard A. Kaslow,Jianming Tang,Eric Hunter,Susan Allen,Joseph Mulenga,S. Branch,T. Roach,Mina John,Simon Mallal,Anthony Ogwu,Roger L. Shapiro,Julia G. Prado,Sarah Fidler,Jonathan Weber,Oliver G. Pybus,Paul Klenerman,Thumbi Ndung'u,Rodney E. Phillips,David E. Heckerman,P.R. Harrigan,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Masafumi Takiguchi,Philip J. R. Goulder,Philip J. R. Goulder +46 more
TL;DR: This process of viral adaptation may dismantle the well-established HLA associations with control of HIV infection that are linked to the availability of key epitopes, and highlights the challenge for a vaccine to keep pace with the changing immunological landscape presented by HIV.
Journal ArticleDOI
Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection
Hayley Crawford,Julia G. Prado,Alasdair Leslie,Stéphane Hué,Isobella Honeyborne,Sharon Reddy,Mary van der Stok,Zenele Mncube,Christian Brander,Christine Rousseau,James I. Mullins,Richard A. Kaslow,Paul A. Goepfert,Susan Allen,Eric Hunter,Joseph Mulenga,Photini Kiepiela,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder,Philip J. R. Goulder +22 more
TL;DR: An escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), is described and demonstrated that this mutation reduces viral replicative capacity.