D
Diana Ekman
Researcher at Science for Life Laboratory
Publications - 44
Citations - 2572
Diana Ekman is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Poison control & Population. The author has an hindex of 21, co-authored 42 publications receiving 2352 citations. Previous affiliations of Diana Ekman include Linköping University & Stockholm University.
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What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?
TL;DR: The results indicate that multiple and repeated domains are enriched in hub proteins and, further, that long disordered regions, which are common in date hubs, are particularly important for flexible binding.
Journal ArticleDOI
Expansion of Protein Domain Repeats
TL;DR: The internal sequence similarity in each protein revealed that the domain repeats are often expanded through duplications of several domains at a time, while the duplication of one domain is less common and the duplication patterns show no dependence on the size of the domains.
Journal ArticleDOI
Arrangements in the modular evolution of proteins
TL;DR: The analysis of protein-domain rearrangements has provided us with functional and evolutionary insights and has aided improved functional predictions and domain assignments to previously uncharacterised genes and proteins.
Journal ArticleDOI
Multi-domain Proteins in the Three Kingdoms of Life: Orphan Domains and Other Unassigned Regions
TL;DR: All eukaryotes have similar fractions of multi-domain proteins and disorder, whereas a high fraction of repeating domain is distinguished only in multicellular eukaries, which implies a role for repeats in cell-cell contacts while the other two features are important for intracellular functions.
Journal ArticleDOI
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats
Amelie Baud,Roel Hermsen,Victor Guryev,Pernilla Stridh,Delyth Graham,Martin W. McBride,Tatiana Foroud,Sophie Calderari,Margarita Diez,Johan Öckinger,Amennai Daniel Beyeen,Alan Gillett,Nada Abdelmagid,André Ortlieb Guerreiro-Cacais,Maja Jagodic,Jonatan Tuncel,Ulrika Norin,Elisabeth Beattie,N. Huynh,William H. Miller,Daniel L. Koller,Imranul Alam,Samreen Falak,Mary Osborne-Pellegrin,Esther Martínez-Membrives,Toni Cañete,Gloria Blázquez,Elia Vicens-Costa,Carme Mont-Cardona,Sira Díaz-Morán,Adolf Tobeña,Oliver Hummel,Diana Zelenika,Kathrin Saar,Giannino Patone,Anja Bauerfeind,M. T. Bihoreau,Matthias Heinig,Young-Ae Lee,Carola Rintisch,Herbert Schulz,D Wheeler,Kim C. Worley,Donna M. Muzny,Richard A. Gibbs,Mark Lathrop,Nico Lansu,Pim W. Toonen,Frans-Paul Ruzius,E. de Bruijn,Heidi Hauser,David J. Adams,Thomas M. Keane,Santosh S. Atanur,Timothy J. Aitman,Paul Flicek,Tomas Malinauskas,E Y Jones,Diana Ekman,R. Lopez-Aumatell,R. Lopez-Aumatell,Anna F. Dominiczak,Martina Johannesson,Rikard Holmdahl,Tomas Olsson,Dominique Gauguier,Norbert Hubner,Alberto Fernández-Teruel,Edwin Cuppen,Richard Mott,Jonathan Flint +70 more
TL;DR: It is shown that the extent and spatial pattern of variation in inbred rats differ substantially from those of inbred mice and that the genetic variants in orthologous genes rarely contribute to the same phenotype in both species.