Nico Lansu

TL;DR: It is shown that the extent and spatial pattern of variation in inbred rats differ substantially from those of inbred mice and that the genetic variants in orthologous genes rarely contribute to the same phenotype in both species.

TL;DR: The study indicates that the genetic characteristics of the hepatic metastases are different from those of the primary CRC tumor, and the choice of treatment in studies investigating targeted therapies should ideally be based on the genetic properties of the metastasis rather than on those ofThe primary tumor.

TL;DR: This work surveys the epigenomic landscape of promoters and cis-regulatory elements in 136 regions of the adult human brain, identifying 83,553 promoter-distal H3K27ac-enriched regions showing global characteristics of brain enhancers and using these data to understand the relevance of noncoding genomic variations previously linked to Parkinson's disease incidence.

TL;DR: An efficient protocol for parallel library preparation and targeted enrichment of pooled multiplexed bar-coded samples for targeted resequencing of large sample collections, and whole-exome or custom mini-genome sequencing projects is presented.

TL;DR: It is demonstrated that integrated analysis of genome-wide TF occupancy, Pol II binding and steady-state RNA levels provide important insights in gene regulatory mechanisms and demonstrate a complementary value in Pol II chip-seq and RNA-seq approaches for better understanding of gene expression regulation.