Diana Yu

TL;DR: HiPSC neuronal phenotypes and gene expression changes associated with SCZD, a complex genetic psychiatric disorder, were reported and key cellular and molecular elements of theSCZD phenotype were ameliorated following treatment of SCZC hiPSC neurons with the antipsychotic loxapine.

TL;DR: The model recapitulates early stages of a human neurodevelopmental disease and represents a promising cellular tool for drug screening, diagnosis and personalized treatment and provides evidence of an unexplored developmental window, before disease onset, in RTT syndrome.

TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is a two-step process, not a single step, like in the previous version of this paper.

TL;DR: It is shown that human cord blood CD133+ cells lose their hematopoietic signature and are converted into CB-induced neuronal-like cells (CB-iNCs) by the ectopic expression of the transcription factor Sox2, a process that is further augmented by the combination of Sox2 and c-Myc.

TL;DR: The possibility of generating mature and functional neurons from Cord Blood (CB) cells without reprogramming into a pluripotent state is shown and the ectopic expression of two transcription factors as well as only one factor allows the generation of proliferating neural progenitor cells starting from CB CD133+ cells.