A
Andrew D. Rhim
Researcher at University of Texas MD Anderson Cancer Center
Publications - 80
Citations - 7660
Andrew D. Rhim is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 28, co-authored 75 publications receiving 6163 citations. Previous affiliations of Andrew D. Rhim include University of Pennsylvania & University of Michigan.
Papers
More filters
Journal ArticleDOI
EMT and Dissemination Precede Pancreatic Tumor Formation
Andrew D. Rhim,Emily T. Mirek,Nicole M. Aiello,Anirban Maitra,Jennifer M. Bailey,Florencia McAllister,Maximilian Reichert,Gregory L. Beatty,Anil K. Rustgi,Robert H. Vonderheide,Steven D. Leach,Ben Z. Stanger +11 more
TL;DR: It is suggested that inflammation enhances cancer progression in part by facilitating EMT and entry into the circulation and tagged cells invaded and entered the bloodstream unexpectedly early, before frank malignancy could be detected by rigorous histologic analysis.
Journal ArticleDOI
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
Andrew D. Rhim,Andrew D. Rhim,Paul E. Oberstein,Dafydd H. Thomas,Emily T. Mirek,Carmine F. Palermo,Stephen A. Sastra,Erin N. Dekleva,Tyler Saunders,Claudia P. Becerra,Ian W. Tattersall,C. Benedikt Westphalen,Jan Kitajewski,Maite G. Fernandez-Barrena,Martin E. Fernandez-Zapico,Christine A. Iacobuzio-Donahue,Kenneth P. Olive,Ben Z. Stanger +17 more
TL;DR: De deleting Shh in a well-defined mouse model of PDAC demonstrated that some components of the tumor stroma can act to restrain tumor growth, and administration of VEGFR blocking antibody selectively improved survival of Shh-deficient tumors.
Journal ArticleDOI
Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer
Lauren J. Bayne,Gregory L. Beatty,Nirag Jhala,Carolyn E. Clark,Andrew D. Rhim,Ben Z. Stanger,Robert H. Vonderheide +6 more
TL;DR: It is shown that tumor-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) is necessary and sufficient to drive the development of Gr-1(+) CD11b(+) cells that suppressed antigen-specific T cells in pancreatic ductal adenocarcinoma.
Journal ArticleDOI
Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer
Nicholas J. Roberts,Alexis L. Norris,Gloria M. Petersen,Melissa L. Bondy,Randall E. Brand,Steven Gallinger,Robert C. Kurtz,Sara H. Olson,Anil K. Rustgi,Ann G. Schwartz,Elena M. Stoffel,Sapna Syngal,George Zogopoulos,Syed Z. Ali,Jennifer E. Axilbund,Kari G. Chaffee,Yun-Ching Chen,Michele L. Cote,Erica J. Childs,Christopher Douville,Fernando S. Goes,Joseph M. Herman,Christine A. Iacobuzio-Donahue,Melissa Kramer,Alvin Makohon-Moore,Richard W. McCombie,K. Wyatt McMahon,Noushin Niknafs,Jennifer Parla,Mehdi Pirooznia,James B. Potash,Andrew D. Rhim,Andrew D. Rhim,Alyssa L. Smith,Yuxuan Wang,Christopher L. Wolfgang,Laura D. Wood,Peter P. Zandi,Michael Goggins,Rachel Karchin,James R. Eshleman,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein,Ralph H. Hruban,Alison P. Klein +45 more
TL;DR: It is demonstrated that the genetic underpinning of inherited pancreatic cancer is highly heterogeneous, which has significant implications for the management of patients with familial Pancreatic cancer and for the identification of susceptibility genes in other common cancer types.
Journal ArticleDOI
Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer.
Yaqing Zhang,Ashley Velez-Delgado,Esha Mathew,Dongjun Li,Flor M. Mendez,Kevin Flannagan,Andrew D. Rhim,Diane M. Simeone,Gregory L. Beatty,Marina Pasca di Magliano +9 more
TL;DR: Derailing this crosstalk between myeloid cells and tumour cells is sufficient to restore anti-tumour immunity mediated by CD8+ T cells, a finding with implications for the design of immune therapies for pancreatic cancer.