D
Diane S. Krause
Researcher at Yale University
Publications - 170
Citations - 36417
Diane S. Krause is an academic researcher from Yale University. The author has contributed to research in topics: Stem cell & Bone marrow. The author has an hindex of 56, co-authored 162 publications receiving 33122 citations. Previous affiliations of Diane S. Krause include University of Pennsylvania & Johns Hopkins University.
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Journal ArticleDOI
Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium
Joanna E. Grove,Carolyn Lutzko,Josef Priller,Octavian Henegariu,Neil D. Theise,Donald B. Kohn,Diane S. Krause +6 more
TL;DR: In this article, the authors investigated the use of retrovirally transduced multipotent bone marrow-derived stem cells (BMSC) to deliver gene therapy to lung epithelium and found that up to 20% of lung epithelial cells can be derived from marrow following BMSC transplantation.
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Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel
Narutoshi Hibino,Gustavo A. Villalona,Nicholas Pietris,Daniel Duncan,Adam Schoffner,Jason D. Roh,Tai Yi,Lawrence W. Dobrucki,Dane Mejias,Rajendra Sawh-Martinez,Jamie K. Harrington,Albert J. Sinusas,Diane S. Krause,Themis R. Kyriakides,W. Mark Saltzman,Jordan S. Pober,Toshiharu Shinoka,Christopher K. Breuer +17 more
TL;DR: This work again finds that seeded BMMCs are lost, declining to 0.02% at 14 d, concomitant with host macrophage invasion, and demonstrates using sex‐mismatched chimeric hosts that bone marrow is not a significant source of endothelial or smooth muscle cells that comprise the neovessel.
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Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes
Jasmijn D.E. de Rooij,Cristyn Branstetter,Jing Ma,Yongjin Li,Michael P. Walsh,Jinjun Cheng,Askar Obulkasim,Jinjun Dang,John Easton,Lonneke J. Verboon,Heather L. Mulder,Martin Zimmermann,Cary Koss,Pankaj Gupta,Michael N. Edmonson,Michael Rusch,Joshua Yew Suang Lim,Katarina Reinhardt,Martina Pigazzi,Guangchun Song,Allen Eng Juh Yeoh,Lee Yung Shih,Der Cherng Liang,Stephanie Halene,Diane S. Krause,Jinghui Zhang,James R. Downing,Franco Locatelli,Dirk Reinhardt,Marry M. van den Heuvel-Eibrink,C. Michel Zwaan,Maarten Fornerod,Tanja A. Gruber +32 more
TL;DR: It is demonstrated that pediatric non-DS-AMKL is a heterogeneous malignancy that can be divided into seven subgroups with varying outcomes, characterized by chimeric oncogenes with cooperating mutations in epigenetic and kinase signaling genes.
Journal ArticleDOI
Limitations of Green Fluorescent Protein as a Cell Lineage Marker
TL;DR: There is considerable variability of expression within and between GFP transgenic strains, and a detailed analysis of GFP expression in one's tissues of interest must guide the choice of reporter mouse strain when GFP is used as a marker of cell lineage or donor origin.
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Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis
Emanuela M. Bruscia,Ping-Xia Zhang,Ayano Satoh,Christina Caputo,Ruslan Medzhitov,Ambika Shenoy,Marie E. Egan,Diane S. Krause +7 more
TL;DR: It is shown that functional CFTR in macrophages influences TLR4 spatial and temporal localization and perturbs LPS-mediated signaling in both murine CF models and patients with CF.