D
Diane S. Krause
Researcher at Yale University
Publications - 170
Citations - 36417
Diane S. Krause is an academic researcher from Yale University. The author has contributed to research in topics: Stem cell & Bone marrow. The author has an hindex of 56, co-authored 162 publications receiving 33122 citations. Previous affiliations of Diane S. Krause include University of Pennsylvania & Johns Hopkins University.
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Journal ArticleDOI
Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator−/− Mice
Emanuela M. Bruscia,Ping-Xia Zhang,Elisa C. Ferreira,Christina Caputo,John W. Emerson,David Tuck,Diane S. Krause,Marie E. Egan +7 more
TL;DR: The hypothesis that macrophages play a role in the exuberant cytokine production and secretion that characterizes CF is supported, suggesting that the macrophage response may be an important therapeutic target for decreasing the morbidity of CF lung disease.
Journal ArticleDOI
Bone Marrow-Derived Cells Contribute to Epithelial Engraftment during Wound Healing
Xenia Borue,Sean Lee,Joanna E. Grove,Erica L. Herzog,Robert G. Harris,Thomas Diflo,Earl J. Glusac,Kevin M Hyman,Neil D. Theise,Diane S. Krause +9 more
TL;DR: It is shown that skin damage affects the degree of engraftment of BMDC as keratinocytes and that the keratinocyte are actively cycling, suggesting that BMDC may assist in early wound healing by engrafting as transit-amplifying cells, which then differentiate into keratin cells.
Journal ArticleDOI
Nonstochastic reprogramming from a privileged somatic cell state.
Shangqin Guo,Xiaoyuan Zi,Vincent P. Schulz,Jijun Cheng,Mei Zhong,Sebastian H.J. Koochaki,Cynthia M. Megyola,Xinghua Pan,Kartoosh Heydari,Sherman M. Weissman,Patrick G. Gallagher,Diane S. Krause,Rong Fan,Jun Lu +13 more
TL;DR: The data demonstrate that the stochastic nature of reprogramming can be overcome in a privileged somatic cell state and suggest that cell-cycle acceleration toward a critical threshold is an important bottleneck for reprograming.
Rapid Communication Marrow-Derived Cells as Vehicles for Delivery of Gene Therapy to Pulmonary Epithelium
Joanna E. Grove,Carolyn Lutzko,Josef Priller,Octavian Henegariu,Neil D. Theise,Donald B. Kohn,Diane S. Krause +6 more
TL;DR: It is demonstrated that highly plastic BMSC can be stably transduced in vitro and retain their ability to differentiate into lung epithelium while maintaining long-term transgene expression.
Journal ArticleDOI
Voltage‐gated potassium conductance in human T lymphocytes stimulated with phorbol ester.
TL;DR: Cell proliferation was equally sensitive to quinine regardless of mitogen, and DNA synthesis by cultures stimulated with TPA, phytohaemagglutinin or succinyl concanavalin A was depressed by the addition of 0.1 mM‐quinine at any point in the culture period.