D
Diane S. Krause
Researcher at Yale University
Publications - 170
Citations - 36417
Diane S. Krause is an academic researcher from Yale University. The author has contributed to research in topics: Stem cell & Bone marrow. The author has an hindex of 56, co-authored 162 publications receiving 33122 citations. Previous affiliations of Diane S. Krause include University of Pennsylvania & Johns Hopkins University.
Papers
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Journal ArticleDOI
IFN-γ binds TPO to inhibit hematopoiesis.
TL;DR: Light is shed on the mechanism of pancytopenia in inflammation, a long-standing clinical observation lacking an explanation, and insight is provided into how the TPO mimetic eltrombopag (ELT) can overcome IFN-γ–mediated inhibition of hematopoiesis.
Journal ArticleDOI
Epithelial (E)-Cadherin Is a Novel Regulator of Platelet Function
Diane S. Krause,Stephanie Halene,Carmen J. Booth,Huiyan Jin,Siying Zou,Alexandra M. Teixeira,Ping-Xia Zhang +6 more
TL;DR: The results demonstrate that E-cadherin contributes to the delicate balance between bleeding, hemostasis, and thrombosis, and extended studies to the human system show impairment of aggregation in response to ADP, epinephrine, andThrombin.
Posted ContentDOI
Methylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation
Hairui Su,Ming Jiang,Ming Jiang,Chamara Senevirathne,Srinivas Aluri,Tuo Zhang,Han Guo,Juliana Xavier-Ferrucio,Shuiling Jin,Ngoc Tung Tran,Szu Mam Liu,Chiao-Wang Sun,Yongxia Zhu,Qing Zhao,Yuling Chen,Lou Ann Cable,Yudao Shen,Jing Liu,Cheng-Kui Qu,Xiaosi Han,Christopher A. Klug,Ravi Bhatia,Yabing Chen,Yabing Chen,Stephen D. Nimer,Y. George Zheng,Camelia Iancu-Rubin,Jian Jin,Haiteng Deng,Diane S. Krause,Jenny Xiang,Amit Verma,Minkui Luo,Minkui Luo,Xinyang Zhao +34 more
TL;DR: A critical role of PRMT1-mediated posttranslational modification of DUSP4 in regulation of Mk differentiation and maturation is demonstrated and a targeting strategy for treatment of thrombocytopenia associated with myeloid malignancies such as MDS is presented.
Journal ArticleDOI
An oxidase road to platelet adhesion.
TL;DR: Collagen receptors are identified as previously unrecognized targets of the extracellular enzyme lysyl oxidase (LOX), the level of which is increased in myeloproliferative neoplasms (MPNs) and other conditions associated with pathological thromboses.
Journal Article
Regulation of chronic lung inflammation to house dust mite allergen by Wnt antagonist (CAM1P.144)
Alfred L. M. Bothwell,Wook-Jin Chae,Alexandra M. Teixeira,Pamela Chan,Liming Hao,Carla V. Rothlin,Diane S. Krause +6 more
TL;DR: The results demonstrate that the Wnt antagonist from activated platelets regulates the early stage of leukocyte infiltration in the challenged tissue, thereby regulating inflammation and type 2 immune responses.