D
Diane S. Krause
Researcher at Yale University
Publications - 170
Citations - 36417
Diane S. Krause is an academic researcher from Yale University. The author has contributed to research in topics: Stem cell & Bone marrow. The author has an hindex of 56, co-authored 162 publications receiving 33122 citations. Previous affiliations of Diane S. Krause include University of Pennsylvania & Johns Hopkins University.
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Journal ArticleDOI
Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction.
Gang Zhi,James B. Wilson,Xiaoyong Chen,Diane S. Krause,Yuxuan Xiao,Nigel J. Jones,Gary M. Kupfer +6 more
TL;DR: In vitro and in vivo experiments show that phosphorylation of S331 is mediated by CHK1, the S-phase checkpoint kinase implicated in the Fanconi anemia DNA repair pathway, and shows that a phosphomimetic mutation at S331 restores all of these phenotypes to wild-type.
Journal ArticleDOI
Engraftment of bone marrow-derived epithelial cells.
John S. Van Arnam,Erica L. Herzog,Joanna E. Grove,Emanuela M. Bruscia,Elizabeth C. Ziegler,Scott Swenson,Diane S. Krause +6 more
TL;DR: In a proof of principal experiment for potential gene therapy applications, it is shown that autologous BM-derived cells transfected with a transgene prior to BM transplantation are able to develop into mature type-II pneumocytes that express the trans-gene.
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Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria
Jian-Kan Guo,Arnaud Marlier,Hongmei Shi,Alan Shan,Thomas Ardito,Zhaopeng Du,Michael Kashgarian,Diane S. Krause,Daniel Biemesderfer,Lloyd G. Cantley +9 more
TL;DR: The data suggest that glomerular proteinuria in the absence of severe structuralglomerular injury activates tubular proliferation, potentially as an adaptive response to minimize the loss of filtered proteins.
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Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator.
Ping-Xia Zhang,Thomas S. Murray,Thomas S. Murray,Valeria Rachela Villella,Eleonora Ferrari,Speranza Esposito,Anthony D. D’Souza,Valeria Raia,Luigi Maiuri,Luigi Maiuri,Diane S. Krause,Marie E. Egan,Emanuela M. Bruscia,Emanuela M. Bruscia +13 more
TL;DR: The results demonstrate that the counterregulatory HO-1/CO pathway, which is critical in balancing and limiting the inflammatory response, is defective in CF MΦs through a CAV-1–dependent mechanism, exacerbating the CF M Φ response to LPS.
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Forskolin effects on the voltage-gated K+ conductance of human T cells.
TL;DR: Forskolin has an effect on T cell mitogenesis that is mediated by inhibition of K+ conductance and is independent of cAMP, which is suggested to inhibit mitogen-induced proliferation of lymphocytes.