D
Diane S. Krause
Researcher at Yale University
Publications - 170
Citations - 36417
Diane S. Krause is an academic researcher from Yale University. The author has contributed to research in topics: Stem cell & Bone marrow. The author has an hindex of 56, co-authored 162 publications receiving 33122 citations. Previous affiliations of Diane S. Krause include University of Pennsylvania & Johns Hopkins University.
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Journal ArticleDOI
Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair.
Huiyan Jin,Andrzej K Ciechanowicz,Alanna R Kaplan,Lin Wang,Ping-Xia Zhang,Yi-Chien Lu,Rachel E Tobin,Brooke A Tobin,Lauren Cohn,Caroline J. Zeiss,Patty J. Lee,Emanuela M. Bruscia,Diane S. Krause +12 more
TL;DR: A novel role for SPC in regulating inflammation via JAK/STAT may have clinical applications, and immunofluorescence revealed increased phosphorylated signal transduction and activation of transcription 3 (pSTAT3), suggesting enhanced Janus kinase (JAK)/STAT activation in inflammatory and AT2 cells of SPC-TK/SPC-KO mice.
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C/EBPε directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx
Stephanie Halene,Peter Gaines,Hong Sun,Theresa Zibello,Sharon Lin,Arati Khanna-Gupta,Simon C. Williams,Archibald S. Perkins,Diane S. Krause,Nancy Berliner +9 more
TL;DR: Two new regulatory functions of C/EBPepsilon in myelopoiesis are shown: in the absence of C/, there is not only incomplete differentiation of granulocytes, but the appearance of an intermediate cell type with monocyte and granulocyte features is disrupted, and the neutrophils have abnormal chemotaxis.
Journal ArticleDOI
Acute aspirin overdose: mechanisms of toxicity.
TL;DR: In this case, medical treatment of several critical concurrent metabolic responses was dependent on frequent evaluations of serum electrolytes, blood and urine pH, blood Po2 blood Pco2, and blood HCO3- concentrations.
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Dynamic Migration and Cell‐Cell Interactions of Early Reprogramming Revealed by High‐Resolution Time‐Lapse Imaging
Cynthia M. Megyola,Yuan Gao,Alexandra M. Teixeira,Jijun Cheng,Kartoosh Heydari,Ee-chun Cheng,Timothy Nottoli,Diane S. Krause,Jun Lu,Shangqin Guo +9 more
TL;DR: An experimental system with multicolor time‐lapse microscopy that permits direct observation of pluripotency induction at single cell resolution, with temporal intervals as short as 5 minutes, and demonstrates that E‐cadherin is required for proper cellular interactions from an early stage of reprogramming, including the two‐cell intermediate.
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MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation.
Xiao Hu,Zongzhi Liu,Zongzhi Liu,Xinyue Chen,Vincent P. Schulz,Abhishek Kumar,Amaleah A. Hartman,Jason S. Weinstein,Jessica F. Johnston,Elisa C. Rodriguez,Anna E. Eastman,Jijun Cheng,Liz Min,Mei Zhong,Christopher W. Carroll,Patrick G. Gallagher,Patrick G. Gallagher,Jun Lu,Martin A. Schwartz,Megan C. King,Diane S. Krause,Shangqin Guo +21 more
TL;DR: It is shown that MKL1 activation in somatic cells reduces chromatin accessibility and hinders full reprogramming to pluripotency and can be bypassed when the Sun2-containing linker of the nucleoskeleton and cytoskeleton (LINC) complex is inhibited.