D
Dick Hoekstra
Researcher at University Medical Center Groningen
Publications - 280
Citations - 19674
Dick Hoekstra is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Vesicle & Lipid bilayer fusion. The author has an hindex of 69, co-authored 280 publications receiving 18789 citations. Previous affiliations of Dick Hoekstra include University of Groningen.
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Vesicle formation of di-normal-alkyl phosphates - liquid-crystalline behavior, myelinization, counterion influence, and stability
TL;DR: The ability to form myelin structures (and indirectly vesicles) appears to be regulated by hydration properties of the DAP crystals, which are mainly determined by the counterion and the alkyl chain length as mentioned in this paper.
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In situ entry of oligonucleotides into brain cells can occur through a nucleic acid channel.
TL;DR: The data imply that for antisense therapy to become effective in brain, cationic lipid-mediated delivery will only be needed for specific cell targeting but not necessarily for delivery per se to accomplish nuclear deposition of oligonucleotides into brain cells and subsequent down-regulation of disease-related targets.
Journal Article
Transport of biosynthetic sphingolipids from Golgi to plasma membrane in HT29 cells: involvement of different carrier vesicle populations.
TL;DR: Density gradient analysis indicates the potential existence of several vesicle populations, distinctly enriched in either lipid, involved in transport of sphingolipids to the plasma membrane in HT29 cells.
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Membrane fusion induced by the major lipid-binding domain of the cytoskeletal protein talin.
TL;DR: This work directly visualized talin peptide-induced vesicle membrane fusion using cryo-electron microscopy, the first example of a cytoskeletal protein domain that can trigger membrane fusion that might be of importance for understanding membrane targeting and motile events at the leading edge of the cell.