Dijana Matak-Vinkovic

TL;DR: It is shown that rotary adenosine triphosphatases (ATPases)/synthases from Thermus thermophilus and Enterococcus hirae can be maintained intact with membrane and soluble subunit interactions preserved in vacuum and can link specific lipid and nucleotide binding with distinct regulatory roles.

TL;DR: The findings indicate that Ctf4 can couple two molecules of Pol α to one CMG helicase within the replisome, providing a new model for lagging-strand synthesis in eukaryotes that resembles the emerging model for the simpler replisomes of Escherichia coli.

TL;DR: It is shown that the PcG protein heterodimer EZH2-EED is necessary and sufficient for binding to the lncRNA HotaIR and that protein recognition occurs within a folded 89-mer domain of HOTAIR.

TL;DR: Novel small molecule inhibitors of FOXM1 that block DNA binding are identified from a high-throughput screen applied to a library of 54,211 small molecules and one of the identified compounds, FDI-6, is characterized in depth and is shown to bind directly toFOXM1 protein, to displace FOXM 1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation.

TL;DR: The architectural and atomic models of both protein complexes described here have been produced in advance of high-resolution structural data and as such provide an initial model for testing hypotheses and planning future experiments.