E
Evan A. Boyle
Researcher at Stanford University
Publications - 38
Citations - 6550
Evan A. Boyle is an academic researcher from Stanford University. The author has contributed to research in topics: Exome sequencing & Genome. The author has an hindex of 26, co-authored 38 publications receiving 5092 citations. Previous affiliations of Evan A. Boyle include University of California, San Diego & Oregon Health & Science University.
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Journal ArticleDOI
An Expanded View of Complex Traits: From Polygenic to Omnigenic
TL;DR: It is proposed that gene regulatory networks are sufficiently interconnected such that all genes expressed in disease-relevant cells are liable to affect the functions of core disease-related genes and that most heritability can be explained by effects on genes outside core pathways.
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Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
Maxwell R. Mumbach,Ansuman T. Satpathy,Evan A. Boyle,Chao Dai,Benjamin G. Gowen,Seung Woo Cho,Michelle L.T. Nguyen,Adam J. Rubin,Jeffrey M. Granja,Katelynn R. Kazane,Yuning Wei,Trieu Nguyen,Peyton Greenside,M. Ryan Corces,Josh Tycko,Dimitre R. Simeonov,Nabeela Suliman,Rui Li,Jin Xu,Ryan A. Flynn,Anshul Kundaje,Paul A. Khavari,Alexander Marson,Alexander Marson,Jacob E. Corn,Thomas Quertermous,William J. Greenleaf,Howard Y. Chang +27 more
TL;DR: It is shown that H3K27ac HiChIP generates high-resolution contact maps of active enhancers and target genes in rare primary human T cell subtypes and coronary artery smooth muscle cells, providing a principled means of assigning molecular functions to autoimmune and cardiovascular disease risk variants.
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Detection of human adaptation during the past 2000 years
Yair Field,Yair Field,Evan A. Boyle,Natalie Telis,Ziyue Gao,Ziyue Gao,Kyle J. Gaulton,Kyle J. Gaulton,David E. Golan,Loic Yengo,Loic Yengo,Ghislain Rocheleau,Philippe Froguel,Philippe Froguel,Mark I. McCarthy,Jonathan K. Pritchard,Jonathan K. Pritchard +16 more
TL;DR: The singleton density score (SDS), a method to infer very recent changes in allele frequencies from contemporary genome sequences, is introduced, suggesting that polygenic adaptation has played a pervasive role in shaping genotypic and phenotypic variation in modern humans.
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Saturation editing of genomic regions by multiplex homology-directed repair
TL;DR: Measurement of the functional consequences of large numbers of mutations with saturation genome editing will potentially facilitate high-resolution functional dissection of both cis-regulatory elements and trans-acting factors, as well as the interpretation of variants of uncertain significance observed in clinical sequencing.
Journal ArticleDOI
Reduced signal for polygenic adaptation of height in UK Biobank.
Jeremy J. Berg,Arbel Harpak,Arbel Harpak,Nasa Sinnott-Armstrong,Anja Moltke Joergensen,Hakhamanesh Mostafavi,Yair Field,Evan A. Boyle,Xinjun Zhang,Fernando Racimo,Jonathan K. Pritchard,Graham Coop +11 more
TL;DR: A new analysis based on the the UK Biobank, a large, independent dataset, finds that the signals of selection using UKB effect estimates are strongly attenuated or absent and the conclusion of strong polygenic adaptation now lacks support.