Hui-Hsin Tsai

TL;DR: It is found that the infant human subventricular zone and RMS contain an extensive corridor of migrating immature neurons before 18 months of age but, contrary to previous reports, this germinal activity subsides in older children and is nearly extinct by adulthood.

TL;DR: It is proposed here that a precise understanding of astrocyte development is critical to defining heterogeneity and could lead advances in understanding and treating a variety of neuropsychiatric diseases.

TL;DR: It is shown that astrocytes are allocated to spatial domains in mouse spinal cord and brain in accordance with their embryonic sites of origin in the ventricular zone, and these domains remain stable throughout life without evidence of secondary tangential migration, even after acute CNS injury.

TL;DR: It is suggested that population of presumptive white matter by oligodendrocyte precursors is dependent on localized expression of CXCL1, and the role for the chemokine C XCL1 and its receptor CXCR2 in patterning the developing spinal cord is demonstrated.

TL;DR: It is shown that C1q protein levels dramatically increase in the normal aging mouse and human brain, by as much as 300-fold, and this increase was predominantly localized in close proximity to synapses and occurred earliest and most dramatically in certain regions of the brain, including some but not all regions known to be selectively vulnerable in neurodegenerative diseases.