Journal ArticleDOI
Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges
TLDR
In this paper, the authors reviewed reported analytical methods and their principles for the quantitative measurement of MDA, HNE and 15(S)-8-iso-PGF2α in biological samples including plasma and urine, and critically discusses their biological and biomedical outcome which is rarely crystal clear and free of artefacts.About:
This article is published in Analytical Biochemistry.The article was published on 2017-05-01. It has received 978 citations till now. The article focuses on the topics: Lipid peroxidation & Malondialdehyde.read more
Citations
More filters
Journal ArticleDOI
Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation.
TL;DR: The roles of oxidative stress, as measured by indices of lipid peroxidation, in diabetes mellitus, atherosclerosis, and chronic inflammation are discussed.
Journal ArticleDOI
Microplastic particles increase arsenic toxicity to rice seedlings.
TL;DR: Microplastic particles and As(III) induced an oxidative burst in rice tissues through mechanical damage and destruction of the tertiary structure of antioxidant enzymes, respectively, thereby increasing O2- and H2O2 in roots and leaves, inducing lipid peroxidation, and destroying cell membranes.
Journal ArticleDOI
Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells.
Shihui Hao,Jiang Yu,Wanming He,Qiong Huang,Yang Zhao,Bishan Liang,Shuyi Zhang,Zhaowei Wen,Shumin Dong,Jinjun Rao,Wangjun Liao,Min Shi +11 more
TL;DR: It is demonstrated that erastin, a classic inducer of ferroptosis, induces this form of cell death in GC cells and that cysteine dioxygenase 1 (CDO1) plays an important role in this process.
Journal ArticleDOI
Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis.
Chainika Khatana,Neeraj K. Saini,Neeraj K. Saini,Sasanka Chakrabarti,Vipin Saini,Anil K. Sharma,Reena V. Saini,Adesh K. Saini +7 more
TL;DR: The Ox-LDL-induced atherogenic mechanism and the treating measures in line to impede the development and progression of atherosclerosis are brief.
Journal ArticleDOI
Effect of flavoring chemicals on free radical formation in electronic cigarette aerosols
Zachary T. Bitzer,Reema Goel,Samantha M. Reilly,Ryan J. Elias,Alexey Silakov,Jonathan Foulds,Joshua E. Muscat,John P. Richie +7 more
TL;DR: The results suggest that flavoring agents play an important role in either enhancing or inhibiting the production of free radicals in flavored e‐cigarette aerosols.
References
More filters
Journal ArticleDOI
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
Book ChapterDOI
Malondialdehyde determination as index of lipid peroxidation
H H Draper,M Hadley +1 more
TL;DR: This chapter describes the malondialdehyde (MDA) as index of lipid peroxidation, a determination that appears to offer a facile means of assessing lipidperoxidation in biological materials.
Journal ArticleDOI
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal.
TL;DR: This review focuses on biochemical concepts of lipidPeroxidation, production, metabolism, and signaling mechanisms of two main omega-6 fatty acids lipid peroxidation products: malondialdehyde (MDA) and, in particular, 4-hydroxy-2-nonenal (4-HNE), summarizing not only its physiological and protective function as signaling molecule stimulating gene expression and cell survival, but also its cytotoxic role inhibiting geneexpression and promoting cell death.
Journal ArticleDOI
Biomarkers of Oxidative Damage in Human Disease
TL;DR: Some of the more commonly used biomarkers of oxidative/nitrosative damage are discussed and selected examples of human studies are included.