D
Dimitris Kioussis
Researcher at National Institute for Medical Research
Publications - 145
Citations - 12763
Dimitris Kioussis is an academic researcher from National Institute for Medical Research. The author has contributed to research in topics: T cell & CD8. The author has an hindex of 61, co-authored 145 publications receiving 12373 citations. Previous affiliations of Dimitris Kioussis include Northwestern University & Instituto de Medicina Molecular.
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"Infectious" transplantation tolerance
Shixin Qin,Stephen P. Cobbold,H Pope,James A. Elliott,Dimitris Kioussis,Joanna D. Davies,Herman Waldmann +6 more
TL;DR: This process of "infectious" tolerance explains why no further immunosuppression was needed to maintain long-term transplantation tolerance in adult mice.
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Transgenic mice with hematopoietic and lymphoid specific expression of Cre.
Jasper de Boer,Adam Williams,George Skavdis,Nicola Harker,Mark Coles,Mauro Tolaini,Trisha Norton,Keith Williams,Kathleen Roderick,Alexandre J. Potocnik,Dimitris Kioussis +10 more
TL;DR: Mouse lines expressing Cre recombinase in hematopoietic tissues using the vav regulatory elements, or in lymphoid cells using the hCD2 promoter and locus control region (LCR) are generated, which will be useful in generating tissue‐specific gene deletions within all the cells of hematoplastic or lymphoid tissues.
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The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.
J.P. Martinez Barbera,Melanie Clements,Paul Q. Thomas,Tristan A. Rodriguez,D. Meloy,Dimitris Kioussis,Rosa S. P. Beddington +6 more
TL;DR: Results demonstrate that Hex function is essential in definitive endoderm for normal development of the forebrain, liver and thyroid gland and chimeric embryos composed of Hex(-/-) cells developing within a wild-type visceral endODerm show forebrain defects indicating that Hex is required in the definitiveendoderm.
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Low avidity recognition of self-antigen by T cells permits escape from central tolerance
George Y. Liu,Paul J. Fairchild,Richard M. Smith,John R. Prowle,Dimitris Kioussis,David C. Wraith +5 more
TL;DR: This work has addressed the hypothesis that the avidity of T cell recognition in the thymus may be compromised, enabling autoreactive T cells to escape self-tolerance by constructing transgenic mice expressing an encephalitogenic T cell receptor (TCR) by using analogs of intermediate affinity.
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Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation
Richard Festenstein,Mauro Tolaini,Paola Corbella,Clio Mamalaki,Jenny Parrington,Margaret Fox,Antigoni Miliou,Margaret Jones,Dimitris Kioussis +8 more
TL;DR: Human CD2 locus control region (LCR) sequences are shown here to be essential for establishing an open chromatin configuration and that a short region, with no enhancer activity, functions in the establishment, maintenance, or both of an open Chromatin domain.