Mark Coles

TL;DR: Mouse lines expressing Cre recombinase in hematopoietic tissues using the vav regulatory elements, or in lymphoid cells using the hCD2 promoter and locus control region (LCR) are generated, which will be useful in generating tissue‐specific gene deletions within all the cells of hematoplastic or lymphoid tissues.

TL;DR: It is shown that deletion of fibroblast activation protein-α (FAPα)+ fibroblasts suppressed both inflammation and bone erosions in mouse models of resolving and persistent arthritis.

TL;DR: Overexpression of E4bp4 was sufficient to increase NK cell production from hematopoietic progenitor cells and acted in a cell-intrinsic manner 'downstream' of the interleukin 15 receptor (IL-15R and through the transcription factor Id2.

TL;DR: It is shown that the haematopoietic cells in the gut exhibit a random pattern of motility before aggregation into the primordia of Peyer’s patches, a major component of the gut-associated lymphoid tissue.

TL;DR: The authors used a transgenic zebrafish model of sterile tissue injury to screen potential factors involved in inflammation resolution and found that tanshinone IIA, which is derived from a Chinese medicinal herb, had proresolving activity by both inducing neutrophil apoptosis and promoting reverse migration of neutrophils.