D
Dominique Dorin-Semblat
Researcher at University of Paris
Publications - 22
Citations - 1253
Dominique Dorin-Semblat is an academic researcher from University of Paris. The author has contributed to research in topics: Plasmodium falciparum & Phosphorylation. The author has an hindex of 15, co-authored 21 publications receiving 1111 citations. Previous affiliations of Dominique Dorin-Semblat include French Institute of Health and Medical Research & Anderson University (Indiana).
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Journal ArticleDOI
Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum
Lev Solyakov,Jean Halbert,Jean Halbert,Mahmood M. Alam,Jean-Phillipe Semblat,Jean-Phillipe Semblat,Dominique Dorin-Semblat,Dominique Dorin-Semblat,Luc Reininger,Luc Reininger,Andrew R. Bottrill,Sharad Mistry,Abdirhaman Abdi,Abdirhaman Abdi,Clare Fennell,Zoe Holland,Claudia Demarta,Yvan Bouza,Audrey Sicard,Audrey Sicard,Marie-Paule Nivez,Sylvain C.P. Eschenlauer,Tenzing Lama,Divya Catherine Thomas,Pushkar Sharma,Shruti Agarwal,Selina Kern,Gabriele Pradel,Michele Graciotti,Andrew B. Tobin,Christian Doerig,Christian Doerig,Christian Doerig +32 more
TL;DR: This work identifies 1177 phosphorylation sites on 650 parasite proteins that are involved in a wide range of general cellular activities such as DNA synthesis, transcription and metabolism as well as key parasite processes such as invasion and cyto-adherence and defines potential anti-malarial drug targets within the parasite kinome.
Journal ArticleDOI
A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites.
Luc Reininger,Oliver Billker,Rita Tewari,Arunima Mukhopadhyay,Clare Fennell,Dominique Dorin-Semblat,Caroline Doerig,Dean Goldring,Leonie Harmse,Lisa C. Ranford-Cartwright,Jeremy Packer,Christian Doerig +11 more
TL;DR: It is demonstrated that Nek-4, a new Plasmodium member of the Nek family, is essential for completion of the sexual cycle of the parasite and for the successful establishment of a malaria infection in the mosquito.
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Functional characterization of both MAP kinases of the human malaria parasite Plasmodium falciparum by reverse genetics.
Dominique Dorin-Semblat,Neils B. Quashie,Jean Halbert,Audrey Sicard,Caroline Doerig,Elizabeth Peat,Lisa C. Ranford-Cartwright,Christian Doerig +7 more
TL;DR: It is demonstrated by using a reverse genetics approach that the map‐2 gene is essential for completion of the asexual cycle of Plasmodium falciparum, an unexpected result in view of the non‐essentiality of the orthologous gene for P. berghei erythrocytic schizogony.
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Disruption of the PfPK7 gene impairs schizogony and sporogony in the human malaria parasite Plasmodium falciparum
Dominique Dorin-Semblat,Audrey Sicard,Caroline Doerig,Lisa C. Ranford-Cartwright,Christian Doerig +4 more
TL;DR: It is shown that PfPK7− parasite clones display phenotypes at two stages of their life cycle: first, a decrease in the rate of asexual growth in erythrocytes associated with a lower number of daughter merozoites generated per schizont, and second, a dramatic reduction in the ability to produce oocysts in the mosquito vector.
Journal ArticleDOI
Malaria: targeting parasite and host cell kinomes.
Christian Doerig,Abdirahman I. Abdi,Abdirahman I. Abdi,Nicholas D. Bland,Nicholas D. Bland,Sylvain C.P. Eschenlauer,Sylvain C.P. Eschenlauer,Dominique Dorin-Semblat,Dominique Dorin-Semblat,Clare Fennell,Clare Fennell,Jean Halbert,Jean Halbert,Zoe Holland,Zoe Holland,Marie-Paule Nivez,Marie-Paule Nivez,Jean Philippe Semblat,Jean Philippe Semblat,Audrey Sicard,Audrey Sicard,Luc Reininger,Luc Reininger +22 more
TL;DR: The taxon-specific kinases possessed by malaria parasites are discussed, and an overview of target PKs that have been validated by reverse genetics are given, either in the human malaria parasite Plasmodium falciparum or in the rodent model Plas modium berghei.