D
Dominique Melck
Researcher at National Research Council
Publications - 69
Citations - 6242
Dominique Melck is an academic researcher from National Research Council. The author has contributed to research in topics: Anandamide & Cannabinoid receptor. The author has an hindex of 36, co-authored 68 publications receiving 5931 citations. Previous affiliations of Dominique Melck include University of Naples Federico II & ARCO.
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Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action.
TL;DR: Research carried out in the past six years has confirmed a similarity between the endocannabinoids and the psychoactive substance in marijuana, delta9(-)-tetrahydrocannabinol, and suggested a role for endoc cannabinoidoids in the modulation of neurotransmitter action and release.
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The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
Luciano De Petrocellis,Dominique Melck,Antonella Palmisano,Tiziana Bisogno,Chiara Laezza,Maurizio Bifulco,Vincenzo Di Marzo +6 more
TL;DR: The data suggest that anandamide blocks human breast cancer cell proliferation through CB1-like receptor-mediated inhibition of endogenous Prolactin action at the level of prolactin receptor.
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N-acyl-dopamines: novel synthetic CB 1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
Tiziana Bisogno,Dominique Melck,Bobrov MYu,Natalia Gretskaya,Vladimir V. Bezuglov,L. De Petrocellis,V. Di Marzo +6 more
TL;DR: It is concluded that NADAs, and AA-DA in particular, may be novel and useful probes for the study of the ECS.
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Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes
TL;DR: The finding of biosynthetic and inactivating mechanisms for AnNH and PEA in macrophages and basophils supports the previously proposed role as local modulators of immune/inflammatory reactions for these two long chain acylethanolamides.
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Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages.
Vincenzo Di Marzo,Tiziana Bisogno,Luciano De Petrocellis,Dominique Melck,Pierangelo Orlando,Jens A. Wagner,George Kunos +6 more
TL;DR: It is found that ionomycin and lipopolysaccharide cause a 24-fold and 2.5-fold stimulation of 2-AG levels in J774 cells, respectively, thus providing unprecedented evidence that this cannabimimetic metabolite can be synthesized by macrophages.