Showing papers by "Dong Wang published in 2012"

A strategy for depositing different types of cells in three dimensions to mimic tubular structures in tissues.

Abstract: The fabrication of tubular structures, with multiple cell types forming different layers of the tube walls, is described using a stress-induced rolling membrane (SIRM). Cell orientation inside the tubes can also be controlled by topographical contact guidance. These layered tubes precisely mimic blood vessels and many other tubular structures, suggesting that they may be of great use in tissue engineering.

A microfluidic flow-stretch chip for investigating blood vessel biomechanics.

Abstract: This microfluidic flow-stretch chip integrates fluid shear stress (FSS) and cyclic stretch (CS), two major mechanical stimulations in cardiovascular systems, for cultured cells. The model chip can deliver FSS and CS simultaneously or independently to vascular cells to mimic the haemodynamic microenvironment of blood vessels in vivo. By imposing FSS-only, CS-only, and FSS+CS stimulation on rat mesenchymal stem cells and human umbilical vein endothelial cells, we found the alignment of the cellular stress fibers varied with cell type and the type of stimulation. The flow-stretch chip is a reliable tool for simulating the haemodynamic microenvironment.

Cantilever driving low frequency piezoelectric energy harvester using single crystal material 0.71Pb(Mg1/3Nb2/3)O3-0.29PbTiO3

Abstract: We present a high performance piezoelectric energy harvester CANtilever Driving Low frequency Energy harvester (CANDLE) consisting of cantilever beam and cymbal transducers based on piezoelectric single crystal 0.71Pb(Mg1/3Nb2/3)O3-0.29PbTiO3. Electrical properties of CANDLE under different proof masses, excitation frequencies, and load resistances are studied systematically. Under an acceleration of 3.2g (g = 9.8 m/s2), a peak voltage of 38 V, a maximum power of 3.7 mW were measured at 102 Hz with a proof mass of 4.2 g. Low resonance frequency and high power output performance demonstrate the promise of the device in energy harvesting for wireless sensors and low-power electronics.

Fluid flow stress induced contraction and re-spread of mesenchymal stem cells: a microfluidic study

Abstract: Mesenchymal stem cells (MSCs), the multipotent progenitor cells, are sensitive to fluid shear stress (FSS). MSCs can migrate through the blood stream by intravasation into the circulatory system to transfer to distant positions through the blood stream. During the transferring process, MSCs may differentiate into cells of corresponding tissues for repair, or remain undifferentiated and initiate ectopic tissue formation, lipid accumulation, or calcification, which are closely related to the pathology of atherosclerosis. However, how the MSCs sense and respond to vascular FSS stimulation and lead to subsequent biological effects remains elusive. In this study, by using an in situ time-lapse microfluidic cell culture and observation system, we found that rat mesenchymal stem cells (rMSCs) presented a contraction and re-spread (CRS) process when they were initially subjected to a physiological FSS (1.3 Pa). Our subsequent studies demonstrated that integrin and cilia played key roles in sensing FSS. Calcium, F-actin, and Rho-kinase were key molecules in the mechanotransduction of the CRS of the rMSCs. Our study revealed the immediate response of the rMSCs to FSS. It will be helpful for the understanding of MSC-related tissue repair and the role of MSCs in the initiation of atherosclerosis.

Probabilistic Joint Remote Preparation of Four-Particle Cluster-Type States with Quaternate Partially Entangled Channels

Abstract: We put forward a new and feasible scheme to realize joint remote preparation of four-particle cluster-type states based on two quaternate partially entangled states as quantum channels. During the preparation, each of the states’ senders is just required to perform a bipartite projective measurement in a 2×2-dimensional Hilbert space, and the receiver needs to implement some appropriate unitary operations including a local triplet collective transformation. It is proved that our scheme can be accomplished in a probabilistic manner, and the success probability of preparation (SPP) is dependent on the entangled states set up in prior. Moreover, it is explored that SPP can be greatly enhanced to be quadruple of that in general case, when the prepared states belong to some special ensembles. And the scheme feasibility is evaluated finally.

Design of a new time-of-flight small-angle neutron scattering instrument at CPHS

Abstract: A new time-of-flight (TOF) small-angle neutron scattering (SANS) diffractometer is to be built at the Compact Pulsed Hadron Source (CPHS) of Tsinghua University, China. This SANS project strives to serve two purposes: its instrumental design, fabrication and optimization will help glean valuable scientific and engineering experiences: and its utilization will help promote fruitful domestic user programs on research of large structures in advanced materials using neutrons. The design draws experiences from other TOF SANS instruments, particularly that of the long-pulse LENS of Indiana University and also considers the source features at CPHS. The design team enjoyed the guidance and assistance from experts through international collaborations. For simultaneous collection of scattering data in the Q-range (similar to 7 x 10(-3) < Q < 1 angstrom(-1)) with reasonable Q-resolution and high efficiency, this instrument is designed to use large area detector (1 x 1 m(2)) and broad wavelength bandwidth (1-10 angstrom) within the first frame. It also pays attention to possible use of optical devices such as neutron guides, focusing lenses and novel detectors. (C) 2011 Elsevier B.V. All rights reserved.