Journal ArticleDOI
A microfluidic flow-stretch chip for investigating blood vessel biomechanics.
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TLDR
This microfluidic flow-stretch chip integrates fluid shear stress (FSS) and cyclic stretch (CS), two major mechanical stimulations in cardiovascular systems, for cultured cells to mimic the haemodynamic microenvironment of blood vessels in vivo.Abstract:
This microfluidic flow-stretch chip integrates fluid shear stress (FSS) and cyclic stretch (CS), two major mechanical stimulations in cardiovascular systems, for cultured cells. The model chip can deliver FSS and CS simultaneously or independently to vascular cells to mimic the haemodynamic microenvironment of blood vessels in vivo. By imposing FSS-only, CS-only, and FSS+CS stimulation on rat mesenchymal stem cells and human umbilical vein endothelial cells, we found the alignment of the cellular stress fibers varied with cell type and the type of stimulation. The flow-stretch chip is a reliable tool for simulating the haemodynamic microenvironment.read more
Citations
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Journal ArticleDOI
Microfluidic platforms for mechanobiology
TL;DR: In this paper, the authors discuss how microfluidics has transformed the study of mechanotransduction and discuss new biological insights that have been elucidated by using micro-fluidic experiments.
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Review on Cell Mechanics: Experimental and Modeling Approaches
TL;DR: A review of novel, experimental approaches and accompanying computational models to the use of microposts for experiments with cells and a bio-chemical-mechanical model for capturing their unique mechanobiological properties.
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Fabrication and multifunction integration of microfluidic chips by femtosecond laser direct writing
TL;DR: In this review, the fundamental principles of femtosecond laser micronanofabrication are introduced and both the preparation and functionalization of advanced microfluidic chips are summarized.
Journal ArticleDOI
3D Bioprinting of Vessel-like Structures with Multilevel Fluidic Channels.
Qing Gao,Zhenjie Liu,Zhiwei Lin,Jingjiang Qiu,Yu Liu,An Liu,Yidong Wang,Meixiang Xiang,Bing Chen,Jianzhong Fu,Yong He +10 more
TL;DR: 3D hydrogel-based vascular structures with multilevel fluidic channels (macro-channel for mechanical stimulation and microchannel for nutrient delivery and chemical stimulation) were fabricated by extrusion-based threeD bioprinting, which could be integrated into organ-on-chip devices that would better simulate the microenvironment of blood vessels.
Journal ArticleDOI
Cardiovascular disease models: A game changing paradigm in drug discovery and screening
Houman Savoji,Houman Savoji,Mohammad Hossein Mohammadi,Mohammad Hossein Mohammadi,Naimeh Rafatian,Masood Khaksar Toroghi,Erika Yan Wang,Yimu Zhao,Anastasia Korolj,Samad Ahadian,Milica Radisic,Milica Radisic +11 more
TL;DR: Current in vitro, in vivo, and in silico platforms for modelling healthy and pathological cardiac tissues and their advantages and disadvantages for drug screening and discovery applications are described and a roadmap for employing these non-animal platforms in assessing drug cardiotoxicity and safety is suggested.
References
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Mesenchymal stem cells in health and disease
TL;DR: The targets and mechanisms of M SC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches are discussed.
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Reconstituting Organ-Level Lung Functions on a Chip
Dongeun Huh,Benjamin D. Matthews,Akiko Mammoto,Martin Montoya-Zavala,Martin Montoya-Zavala,Hong Yuan Hsin,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +8 more
TL;DR: Mechanically active “organ-on-a-chip” microdevices that reconstitute tissue-tissue interfaces critical to organ function may expand the capabilities of cell culture models and provide low-cost alternatives to animal and clinical studies for drug screening and toxicology applications.
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Soft Lithography in Biology and Biochemistry
TL;DR: Soft lithography offers the ability to control the molecular structure of surfaces and to pattern the complex molecules relevant to biology, to fabricate channel structures appropriate for microfluidics, and topattern and manipulate cells.
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Cells on chips
TL;DR: Highly integrated microdevices show great promise for basic biomedical and pharmaceutical research, and robust and portable point-of-care devices could be used in clinical settings, in both the developed and the developing world.