D
Dongyeop Kim
Researcher at University of Pennsylvania
Publications - 53
Citations - 2005
Dongyeop Kim is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Biofilm & Streptococcus mutans. The author has an hindex of 19, co-authored 44 publications receiving 1276 citations. Previous affiliations of Dongyeop Kim include University of Rochester & Chonbuk National University.
Papers
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Journal ArticleDOI
pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence.
Benjamin Horev,Benjamin Horev,Marlise I. Klein,Marlise I. Klein,Geelsu Hwang,Geelsu Hwang,Yong Li,Yong Li,Dongyeop Kim,Dongyeop Kim,Hyun Koo,Hyun Koo,Danielle S. W. Benoit,Danielle S. W. Benoit +13 more
TL;DR: Farnesol-loaded nanoparticles effectively attenuated biofilm virulence in vivo using a clinically relevant topical treatment regimen in a rodent dental caries disease model and have great potential to enhance the efficacy of antibiofilm agents through multitargeted binding and pH-responsive drug release due to microenvironmental triggers.
Journal ArticleDOI
Nanocatalysts promote Streptococcus mutans biofilm matrix degradation and enhance bacterial killing to suppress dental caries in vivo
Lizeng Gao,Yuan Liu,Dongyeop Kim,Yong Li,Geelsu Hwang,Pratap C. Naha,David P. Cormode,Hyun Koo +7 more
TL;DR: A novel strategy to control plaque-biofilms using catalytic nanoparticles (CAT-NP) with peroxidase-like activity that trigger extracellular matrix degradation and cause bacterial death within acidic niches of caries-causing biofilm is reported.
Journal ArticleDOI
Dextran-Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption
Pratap C. Naha,Yuan Liu,Geelsu Hwang,Yue Huang,Sarah Gubara,Venkata S. Jonnakuti,Aurea Simon-Soro,Dongyeop Kim,Lizeng Gao,Hyun Koo,David P. Cormode +10 more
TL;DR: Dextran-coated iron oxide nanoparticles termed nanozymes (Dex-NZM) that display strong catalytic (peroxidase-like) activity at acidic pH values, target biofilms with high specificity, and prevent severe caries without impacting surrounding oral tissues in vivo are reported.
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Candida albicans stimulates Streptococcus mutans microcolony development via cross-kingdom biofilm-derived metabolites.
Dongyeop Kim,Arjun Sengupta,Tagbo H.R. Niepa,Byung-Hoo Lee,Aalim M. Weljie,Verônica Santana de Freitas-Blanco,Ramiro Mendonça Murata,Kathleen J. Stebe,Daeyeon Lee,Hyun Koo +9 more
TL;DR: The data revealed that bacterial-fungal derived conditioned medium (BF-CM) significantly increased the growth of S. mutans and altered biofilm 3D-architecture in a dose-dependent manner, resulting in enlarged and densely packed bacterial cell-clusters (microcolonies).
Journal ArticleDOI
Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo
TL;DR: It is reported that mannans located on the outer surface of C. albicans cell-wall mediates GtfB binding, enhancing glucan-matrix production and modulating bacterial-fungal association within biofilms formed in vivo.