Aalim M. Weljie

TL;DR: The technique is validated against a traditional "spectral binning" analysis on the basis of sensitivity to water suppression, relaxation effects, and NMR spectral acquisition times using PCA pattern recognition analysis.

TL;DR: High consumption of fermentable substrate in vegans was not associated with higher levels of faecal short chain fatty acids, a finding confirmed in a 10-day controlled feeding experiment, and residence in globally distinct societies helps determine the composition of the gut microbiota that influences the production of diet-dependent gut microbial metabolites.

TL;DR: Differences in gender, diurnal variation, and age in a human population are explored and targeted profiling produces robust models, generates accurate metabolite concentration data, and provides data that can be used to help understand metabolic differences in a healthy population.

TL;DR: PPARGC1a is leveraged, a transcriptional coactivator that regulates broad programs of fatty acid consumption, to identify 3-hydroxyisobutyrate (3-HIB), a catabolic intermediate of the BCAA valine, as a new paracrine regulator of trans-endothelial fatty acid transport, providing a mechanistic explanation for how increased BCAA catabolic flux can cause diabetes.

TL;DR: It is shown that, upon genetic deletion of Acly, the gene coding for ATP-citrate lyase (ACLY), cells remain viable and proliferate, although at an impaired rate, and engagement of acetate metabolism is a crucial, although partial, mechanism of compensation for ACLY deficiency.