A
Arjun Sengupta
Researcher at University of Pennsylvania
Publications - 45
Citations - 1515
Arjun Sengupta is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 38 publications receiving 1088 citations. Previous affiliations of Arjun Sengupta include Tata Institute of Fundamental Research & Indian Institute of Technology Kharagpur.
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Journal ArticleDOI
ATP-citrate lyase controls a glucose-to-acetate metabolic switch
Steven Zhao,AnnMarie Torres,Ryan A. Henry,Sophie Trefely,Martina Wallace,Joyce V. Lee,Alessandro Carrer,Arjun Sengupta,Sydney L. Campbell,Yin-Ming Kuo,Alexander J. Frey,Noah Meurs,John M. Viola,Ian A. Blair,Aalim M. Weljie,Christian M. Metallo,Nathaniel W. Snyder,Andrew J. Andrews,Kathryn E. Wellen +18 more
TL;DR: It is shown that, upon genetic deletion of Acly, the gene coding for ATP-citrate lyase (ACLY), cells remain viable and proliferate, although at an impaired rate, and engagement of acetate metabolism is a crucial, although partial, mechanism of compensation for ACLY deficiency.
Journal ArticleDOI
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells
Brian J. Altman,Annie L. Hsieh,Annie L. Hsieh,Arjun Sengupta,Saikumari Y. Krishnanaiah,Zachary E. Stine,Zandra E. Walton,Arvin M. Gouw,Anand Venkataraman,Bo Li,Pankuri Goraksha-Hicks,Sharon J. Diskin,David I. Bellovin,M. Celeste Simon,Jeffrey C. Rathmell,Mitchell A. Lazar,John M. Maris,Dean W. Felsher,John B. Hogenesch,Aalim M. Weljie,Chi V. Dang +20 more
TL;DR: It is reported here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly inducing REV-ERBα to dampen expression and oscillation of BMAL1, and this could be rescued by knockdown of REV -ERB.
Journal ArticleDOI
Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism
Saikumari Y. Krishnaiah,Gang Wu,Gang Wu,Brian J. Altman,Jacqueline Growe,Seth D. Rhoades,Faith Coldren,Anand Venkataraman,Anthony O. Olarerin-George,Lauren J. Francey,Lauren J. Francey,Sarmistha Mukherjee,Saiveda Girish,Christopher P. Selby,Sibel Cal,Ubeydullah Er,Bahareh Sianati,Arjun Sengupta,Ron C. Anafi,I. Halil Kavakli,Aziz Sancar,Joseph A. Baur,Chi V. Dang,John B. Hogenesch,John B. Hogenesch,Aalim M. Weljie +25 more
TL;DR: These results provide the first comprehensive views of circadian liver and cell-autonomous metabolism and Surprisingly, CRY1 knockdown induced 8 hr rhythms in amino acid, methylation, and vitamin metabolites, decoupling metabolite from transcriptional rhythms, with potential impact on nutrient sensing in vivo.
Journal ArticleDOI
Candida albicans stimulates Streptococcus mutans microcolony development via cross-kingdom biofilm-derived metabolites.
Dongyeop Kim,Arjun Sengupta,Tagbo H.R. Niepa,Byung-Hoo Lee,Aalim M. Weljie,Verônica Santana de Freitas-Blanco,Ramiro Mendonça Murata,Kathleen J. Stebe,Daeyeon Lee,Hyun Koo +9 more
TL;DR: The data revealed that bacterial-fungal derived conditioned medium (BF-CM) significantly increased the growth of S. mutans and altered biofilm 3D-architecture in a dose-dependent manner, resulting in enlarged and densely packed bacterial cell-clusters (microcolonies).
Journal ArticleDOI
Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt
Aalim M. Weljie,Peter Meerlo,Namni Goel,Arjun Sengupta,Matthew S. Kayser,Ted Abel,Morris J. Birnbaum,David F. Dinges,Amita Sehgal +8 more
TL;DR: Data from a rat model and human clinical study of chronic sleep restriction are presented, revealing that two metabolites in blood, oxalic acid and diacylglycerol 36:3, are quantitatively depleted under sleep-restricted conditions and restored after recovery sleep.