C
Christopher Cawthorne
Researcher at Katholieke Universiteit Leuven
Publications - 80
Citations - 2171
Christopher Cawthorne is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: In vivo & Medicine. The author has an hindex of 20, co-authored 69 publications receiving 1530 citations. Previous affiliations of Christopher Cawthorne include University of Hull & University of Manchester.
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Journal ArticleDOI
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.
Janine T. Erler,Christopher Cawthorne,Kaye J. Williams,Marianne Koritzinsky,Bradley G Wouters,Claire Wilson,Crispin J. Miller,Costas Demonacos,Ian J. Stratford,Caroline Dive +9 more
TL;DR: The contribution of Bid and/or Bax down-regulation to drug responsiveness was demonstrated by the relative resistance of normoxic cells that had no or reduced expression of Bid or Bax and by the finding that forcedexpression of Bid in hypoxic cells resulted in increased sensitivity to the topoisomerase II inhibitor etoposide.
Journal ArticleDOI
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity
Suzanne J.F. Kaptein,Sofie Jacobs,Lana Langendries,Laura Seldeslachts,Sebastiaan ter Horst,Laurens Liesenborghs,Bart Hens,Valentijn Vergote,Elisabeth Heylen,Karine Barthélémy,Elke Maas,Carolien De Keyzer,Lindsey Bervoets,Jasper Rymenants,Tina Van Buyten,Xin Zhang,Rana Abdelnabi,Juanita Pang,Rachel Williams,Hendrik Jan Thibaut,Kai Dallmeier,Robbert Boudewijns,Jens Wouters,Patrick Augustijns,Nick Verougstraete,Christopher Cawthorne,Judith Breuer,Caroline Solas,Birgit Weynand,Pieter Annaert,Isabel Spriet,Greetje Vande Velde,Johan Neyts,Johan Neyts,Joana Rocha-Pereira,Leen Delang +35 more
TL;DR: In vivo preclinical results with favipiravir indicate that antiviral efficacy against SARS-CoV-2 might only be achieved with a very high dose, whereas hydroxychloroquine, completely lacks antiviral activity, provides no scientific basis for its further use in COVID-19 patients and demonstrates that an antiviral drug at nontoxic doses exhibits a marked protective effect in a small animal model.
Journal ArticleDOI
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Robbert Boudewijns,Robbert Boudewijns,Hendrik Jan Thibaut,Hendrik Jan Thibaut,Suzanne J.F. Kaptein,Suzanne J.F. Kaptein,Rong Li,Valentijn Vergote,Laura Seldeslachts,Johan Van Weyenbergh,Carolien De Keyzer,Carolien De Keyzer,Lindsey Bervoets,Lindsey Bervoets,Sapna Sharma,Sapna Sharma,Laurens Liesenborghs,Laurens Liesenborghs,Ji Ma,Ji Ma,Sander Jansen,Sander Jansen,Dominique Van Looveren,Dominique Van Looveren,Thomas Vercruysse,Thomas Vercruysse,Xinyu Wang,Xinyu Wang,Dirk Jochmans,Dirk Jochmans,Erik Martens,Kenny Roose,Dorien De Vlieger,Bert Schepens,Tina Van Buyten,Tina Van Buyten,Sofie Jacobs,Sofie Jacobs,Yanan Liu,Joan Martí-Carreras,Bert Vanmechelen,Tony Wawina-Bokalanga,Leen Delang,Leen Delang,Joana Rocha-Pereira,Joana Rocha-Pereira,Lotte Coelmont,Lotte Coelmont,Winston Chiu,Winston Chiu,Pieter Leyssen,Pieter Leyssen,Elisabeth Heylen,Elisabeth Heylen,Dominique Schols,Lanjiao Wang,Lanjiao Wang,Lila Close,Jelle Matthijnssens,Marc Van Ranst,Veerle Compernolle,Georg Schramm,Koen Van Laere,Xavier Saelens,Nico Callewaert,Ghislain Opdenakker,Piet Maes,Birgit Weynand,Christopher Cawthorne,Greetje Vande Velde,Zhongde Wang,Johan Neyts,Johan Neyts,Kai Dallmeier,Kai Dallmeier +74 more
TL;DR: The results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients.
Journal ArticleDOI
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate.
Lorena Sanchez-Felipe,Lorena Sanchez-Felipe,Thomas Vercruysse,Sapna Sharma,Sapna Sharma,Ji Ma,Ji Ma,Viktor Lemmens,Viktor Lemmens,Dominique Van Looveren,Mahadesh Prasad Arkalagud Javarappa,Mahadesh Prasad Arkalagud Javarappa,Robbert Boudewijns,Robbert Boudewijns,Bert Malengier-Devlies,Laurens Liesenborghs,Laurens Liesenborghs,Suzanne J.F. Kaptein,Suzanne J.F. Kaptein,Carolien De Keyzer,Carolien De Keyzer,Lindsey Bervoets,Lindsey Bervoets,Sarah Debaveye,Sarah Debaveye,Madina Rasulova,Laura Seldeslachts,Li Hsin Li,Li Hsin Li,Sander Jansen,Sander Jansen,Michael Bright Yakass,Michael Bright Yakass,Michael Bright Yakass,Babs E. Verstrepen,Kinga P. Böszörményi,Gwendoline Kiemenyi-Kayere,Nikki van Driel,Osbourne Quaye,Osbourne Quaye,Xin Zhang,Xin Zhang,Sebastiaan ter Horst,Sebastiaan ter Horst,Niraj Mishra,Niraj Mishra,Niraj Mishra,Ward Deboutte,Jelle Matthijnssens,Lotte Coelmont,Lotte Coelmont,Corinne Vandermeulen,Elisabeth Heylen,Valentijn Vergote,Dominique Schols,Zhongde Wang,Willy M. J. M. Bogers,Thijs Kuiken,Ernst J. Verschoor,Christopher Cawthorne,Koen Van Laere,Ghislain Opdenakker,Greetje Vande Velde,Birgit Weynand,Dirk E. Teuwen,Patrick Matthys,Johan Neyts,Johan Neyts,Hendrik Jan Thibaut,Kai Dallmeier,Kai Dallmeier +70 more
TL;DR: The quality of immune responses triggered and the rapid kinetics by which protective immunity can be mounted already after a single dose warrant further development of this potent SARS-CoV-2 vaccine candidate.
Journal ArticleDOI
[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
Hervé Boutin,Christian Prenant,Renaud Maroy,James Galea,James Galea,Andrew D. Greenhalgh,Alison Smigova,Christopher Cawthorne,Peter J Julyan,Shane M. Wilkinson,Samuel D. Banister,Gavin Brown,Karl Herholz,Michael Kassiou,Nancy J. Rothwell +14 more
TL;DR: The results suggest that, with the longer half-life of [ 18F] which facilitates distribution of the tracer across PET centre, [18F]DPA-714 is a good alternative for TSPO imaging.