Douglas King

TL;DR: The divergence of RIS target frequency between transduced progenitor cells and post-thymic T lymphocytes indicates that vector integration influences cell survival, engraftment, or proliferation.

TL;DR: There is likely to be a limitation to initiation of normal thymopoiesis, and intervention for patients with typical X-linked severe combined immunodeficiency should be considered as early as possible.

TL;DR: It is suggested that a chimeric TCR repertoire, comprising T‐cell clones developed before and after transplant, can be associated with clinical remission from severe arthritis.

TL;DR: Although the T‐cell receptor Vβ repertoire was not altered after retroviral transduction, there were notable shifts in subset profiles with an increased proportion of CD45RO cells in transduced populations, which may explain the lower than expected levels of GVHD and poor antiviral immunity reported in recent trials.

TL;DR: This chapter focuses on the study of T-cells obtained from the synovial fluid of patients with inflammatory arthritis, using two alternative molecular methods to analyse TCR diversity, identify clonal expansions, and track specific T-cell populations over both time and location.