K
Karin Pike-Overzet
Researcher at Leiden University Medical Center
Publications - 49
Citations - 3679
Karin Pike-Overzet is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Stem cell & T cell. The author has an hindex of 23, co-authored 44 publications receiving 3253 citations. Previous affiliations of Karin Pike-Overzet include Erasmus University Medical Center & Erasmus University Rotterdam.
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Journal ArticleDOI
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
Steven J. Howe,Marc R. Mansour,Kerstin Schwarzwaelder,Cynthia C. Bartholomae,Mike Hubank,Helena Kempski,Martijn H. Brugman,Karin Pike-Overzet,S Chatters,Dick de Ridder,Dick de Ridder,Kimberly Gilmour,Stuart Adams,Susannah I. Thornhill,Kathryn L. Parsley,Frank J. T. Staal,Rosemary E. Gale,David C. Linch,Jinhua Bayford,Lucie Brown,Michelle Quaye,Christine Kinnon,Philip Ancliff,David Webb,Manfred Schmidt,Christof von Kalle,H. Bobby Gaspar,Adrian J. Thrasher +27 more
TL;DR: The occurrence of clonal T cell acute lymphoblastic leukemia (T-ALL) promoted by insertional mutagenesis in a completed gene therapy trial of 10 SCID-X1 patients is described and a general toxicity of endogenous gammaretroviral enhancer elements is highlighted.
Journal ArticleDOI
New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling
Willem A. Dik,Karin Pike-Overzet,Floor Weerkamp,Dick de Ridder,Dick de Ridder,Edwin F. E. de Haas,Miranda R. M. Baert,Peter J. van der Spek,Esther E. L. Koster,Marcel J. T. Reinders,Jacques J.M. van Dongen,Anton W. Langerak,Frank J. T. Staal +12 more
TL;DR: The TCR rearrangement data demonstrate that a number of key events occur earlier than assumed previously; therefore, human T cell development is much more similar to murine T cellDevelopment than reported before.
Journal ArticleDOI
Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
Irene Homminga,Rob Pieters,Anton W. Langerak,Johan J. de Rooi,Andrew P. Stubbs,Monique Verstegen,Maartje Vuerhard,Jessica Buijs-Gladdines,Clarissa Kooi,Petra Klous,Petra Klous,Pieter Van Vlierberghe,Adolfo A. Ferrando,Jean Michel Cayuela,Brenda Verhaaf,H. Berna Beverloo,Martin A. Horstmann,Valerie de Haas,Anna-Sophia Wiekmeijer,Karin Pike-Overzet,Frank J. T. Staal,Wouter de Laat,Wouter de Laat,Jean Soulier,François Sigaux,Jules P.P. Meijerink +25 more
TL;DR: NKX2-1, NKX22-2, and MEF2C are proposed as T-ALL oncogenes that are activated by various rearrangements.
Journal ArticleDOI
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
Annette Deichmann,Salima Hacein-Bey-Abina,Manfred Schmidt,Manfred Schmidt,Alexandrine Garrigue,Martijn H. Brugman,Jingqiong Hu,Hanno Glimm,Gabor Gyapay,Bernard Prum,Christopher Fraser,Nicolas Fischer,Kerstin Schwarzwaelder,Kerstin Schwarzwaelder,Maria Luise Siegler,Dick de Ridder,Dick de Ridder,Karin Pike-Overzet,Steven J. Howe,Adrian J. Thrasher,Gerard Wagemaker,Ulrich Abel,Frank J. T. Staal,Eric Delabesse,Jean-Luc Villeval,Bruce J. Aronow,Christophe Hue,Claudia Prinz,Manuela Wissler,Chuck Klanke,Jean Weissenbach,Ian E. Alexander,Alain Fischer,Christof von Kalle,Marina Cavazzana-Calvo +34 more
TL;DR: The results obtained from a large-scale mapping of retroviral integration sites isolated from cells of 9 patients with X-linked SCID (SCID-X1) treated with a retrovirus-based gene therapy protocol help to elucidate the relationship between vector insertion and long-term in vivo selection of transduced cells in human patients with SCID- X1.
Journal ArticleDOI
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo
Kerstin Schwarzwaelder,Steven J. Howe,Manfred Schmidt,Manfred Schmidt,Martijn H. Brugman,Annette Deichmann,Annette Deichmann,Hanno Glimm,Hanno Glimm,Sonja Schmidt,Claudia Prinz,Manuela Wissler,Douglas King,Fang Zhang,Kathryn L. Parsley,Kimberly Gilmour,Joanna Sinclair,Jinhua Bayford,Rachel Peraj,Karin Pike-Overzet,Frank J. T. Staal,Dick de Ridder,Dick de Ridder,Christine Kinnon,Ulrich Abel,Gerard Wagemaker,H. Bobby Gaspar,Adrian J. Thrasher,Christof von Kalle +28 more
TL;DR: The divergence of RIS target frequency between transduced progenitor cells and post-thymic T lymphocytes indicates that vector integration influences cell survival, engraftment, or proliferation.