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Annette Deichmann
Researcher at German Cancer Research Center
Publications - 22
Citations - 2410
Annette Deichmann is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Genetic enhancement & Gene. The author has an hindex of 15, co-authored 21 publications receiving 2305 citations. Previous affiliations of Annette Deichmann include University of Freiburg.
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Journal ArticleDOI
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Marion Ott,Manfred Schmidt,Kerstin Schwarzwaelder,Stefan Stein,Ulrich Siler,Ulrike Koehl,Hanno Glimm,K. Kühlcke,Andrea Schilz,Hana Kunkel,Sonja Naundorf,Andrea Brinkmann,Annette Deichmann,Marlene Fischer,Claudia R. Ball,Ingo H. Pilz,Cynthia E. Dunbar,Yang Du,Nancy A. Jenkins,Neal G. Copeland,Ursula Lüthi,Moustapha Hassan,Adrian J. Thrasher,Dieter Hoelzer,Christof von Kalle,Reinhard Seger,Manuel Grez +26 more
TL;DR: The results suggest that gene therapy in combination with bone marrow conditioning can be successfully used to treat inherited diseases affecting the myeloid compartment such as CGD.
Journal ArticleDOI
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
Annette Deichmann,Salima Hacein-Bey-Abina,Manfred Schmidt,Manfred Schmidt,Alexandrine Garrigue,Martijn H. Brugman,Jingqiong Hu,Hanno Glimm,Gabor Gyapay,Bernard Prum,Christopher Fraser,Nicolas Fischer,Kerstin Schwarzwaelder,Kerstin Schwarzwaelder,Maria Luise Siegler,Dick de Ridder,Dick de Ridder,Karin Pike-Overzet,Steven J. Howe,Adrian J. Thrasher,Gerard Wagemaker,Ulrich Abel,Frank J. T. Staal,Eric Delabesse,Jean-Luc Villeval,Bruce J. Aronow,Christophe Hue,Claudia Prinz,Manuela Wissler,Chuck Klanke,Jean Weissenbach,Ian E. Alexander,Alain Fischer,Christof von Kalle,Marina Cavazzana-Calvo +34 more
TL;DR: The results obtained from a large-scale mapping of retroviral integration sites isolated from cells of 9 patients with X-linked SCID (SCID-X1) treated with a retrovirus-based gene therapy protocol help to elucidate the relationship between vector insertion and long-term in vivo selection of transduced cells in human patients with SCID- X1.
Journal ArticleDOI
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo
Kerstin Schwarzwaelder,Steven J. Howe,Manfred Schmidt,Manfred Schmidt,Martijn H. Brugman,Annette Deichmann,Annette Deichmann,Hanno Glimm,Hanno Glimm,Sonja Schmidt,Claudia Prinz,Manuela Wissler,Douglas King,Fang Zhang,Kathryn L. Parsley,Kimberly Gilmour,Joanna Sinclair,Jinhua Bayford,Rachel Peraj,Karin Pike-Overzet,Frank J. T. Staal,Dick de Ridder,Dick de Ridder,Christine Kinnon,Ulrich Abel,Gerard Wagemaker,H. Bobby Gaspar,Adrian J. Thrasher,Christof von Kalle +28 more
TL;DR: The divergence of RIS target frequency between transduced progenitor cells and post-thymic T lymphocytes indicates that vector integration influences cell survival, engraftment, or proliferation.
Journal ArticleDOI
Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis
Ute Modlich,Olga S. Kustikova,Manfred G. Schmidt,Cornelia Rudolph,Johann Meyer,Zhixiong Li,Kenji Kamino,Nils von Neuhoff,Brigitte Schlegelberger,Klaus Kuehlcke,Kevin D. Bunting,Sonja Schmidt,Annette Deichmann,Christof von Kalle,Boris Fehse,Christopher Baum +15 more
TL;DR: It is shown that leukemias associated with retroviral expression of MDR1 depend on high vector dose, and involve the selection of clones with combinatorial insertional mutagenesis of proto-oncogenes or other signaling genes, and that insertional mutants can be amplified in vitro before transplantation.
Journal ArticleDOI
Comprehensive genomic access to vector integration in clinical gene therapy
Richard Gabriel,R Eckenberg,Anna Paruzynski,Cynthia C. Bartholomae,Ali Nowrouzi,Anne Arens,Steven J. Howe,Alessandra Recchia,Claudia Cattoglio,Wei Wang,Katrin Faber,Kerstin Schwarzwaelder,Romy Kirsten,Annette Deichmann,Claudia R. Ball,Kamaljit S. Balaggan,Rafael J. Yáñez-Muñoz,Robin R. Ali,H. Bobby Gaspar,Luca Biasco,Alessandro Aiuti,Daniela Cesana,Eugenio Montini,Luigi Naldini,Odile Cohen-Haguenauer,Fulvio Mavilio,Adrian J. Thrasher,Adrian J. Thrasher,Hanno Glimm,Christof von Kalle,William Saurin,Manfred Schmidt +31 more
TL;DR: A model to define genomic access to the viral integration site that provides optimal restriction motif combinations and minimizes the percentage of nonaccessible insertion loci is developed and a new nonrestrictive LAM-PCR approach is introduced.