Dylan H. Goldman

TL;DR: It is demonstrated that therapeutic engraftment of brain-engrafting macrophages may be possible with irradiation-free conditioning regimens and that beM&phgr;s maintain a unique functional and transcriptional identity as compared with microglia.

TL;DR: This paper showed that ablation of meningeal lymphatic vessels in 5xFAD mice (a mouse model of amyloid deposition that expresses five mutations found in familial AD) worsened the outcome of mice treated with anti-Aβ passive immunotherapy by exacerbating the deposition of Aβ, microgliosis, neurovascular dysfunction, and behavioural deficits.

TL;DR: The authors showed that IL-4Rα knockout in inhibitory (but not in excitatory) neurons was sufficient to impair contextual fear memory, and snRNA-seq from these mice pointed to IL4driven regulation of synaptic function in promoting memory.

TL;DR: In this article, the effects of T cells on synaptic function and episodic memory were elucidated, and it was shown that depletion of CD4 T cells led to memory deficits and impaired long term potentiation.

TL;DR: In this article , the authors demonstrate that meningeal lymphatics both assist microglial activation and support the behavioral response to peripheral inflammation, and they identify dysregulated genes and biological pathways, common to both experimental lymphatic ablation and aging.