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Richard J. Perrin
Researcher at Washington University in St. Louis
Publications - 75
Citations - 3630
Richard J. Perrin is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Alzheimer's disease & Dementia. The author has an hindex of 18, co-authored 75 publications receiving 2367 citations.
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Journal ArticleDOI
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
TL;DR: Studies using new neuroimaging techniques and fluid biomarkers suggest that Alzheimer's disease pathology can be detected preclinically, which should allow the design of new clinical trials and early mechanism-based therapeutic intervention.
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YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease
Rebecca Craig-Schapiro,Richard J. Perrin,Catherine M. Roe,Chengjie Xiong,Deborah Carter,Nigel J. Cairns,Mark A. Mintun,Elaine R. Peskind,Elaine R. Peskind,Ge Li,Douglas Galasko,Christopher M. Clark,Joseph F. Quinn,Gina D'Angelo,James P. Malone,R. Reid Townsend,John C. Morris,Anne M. Fagan,David M. Holtzman +18 more
TL;DR: These data demonstrate that YKL-40, a putative indicator of neuroinflammation, is elevated in AD and, together with Aβ42, has potential prognostic utility as a biomarker for preclinical AD.
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A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease.
Nicolas R. Barthélemy,Yan Li,Nelly Joseph-Mathurin,Brian A. Gordon,Jason Hassenstab,Tammie L.S. Benzinger,Virginia Buckles,Anne M. Fagan,Richard J. Perrin,Alison Goate,John C. Morris,Celeste M. Karch,Chengjie Xiong,Ricardo F. Allegri,Patricio Chrem Mendez,Sarah B. Berman,Takeshi Ikeuchi,Hiroshi Mori,Hiroyuki Shimada,Mikio Shoji,Kazushi Suzuki,James M. Noble,Martin R. Farlow,Jasmeer P. Chhatwal,Neill R. Graff-Radford,Stephen Salloway,Stephen Salloway,Peter R. Schofield,Peter R. Schofield,Colin L. Masters,Colin L. Masters,Ralph N. Martins,Antoinette O'Connor,Nick C. Fox,Johannes Levin,Johannes Levin,Mathias Jucker,Mathias Jucker,Audrey Gabelle,Sylvain Lehmann,Chihiro Sato,Randall J. Bateman,Eric McDade +42 more
TL;DR: A pattern of tau staging is identified where site-specific phosphorylation changes occur at different periods of disease progression and follow distinct trajectories over time, providing insights into the pathways linking tau, amyloid-β and neurodegeneration in dominantly inherited Alzheimer's disease.
Journal ArticleDOI
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
William T. Hu,Holtzman David M,Anne M. Fagan,Leslie M. Shaw,Richard J. Perrin,Steven E. Arnold,Murray Grossman,Chengjie Xiong,Rebecca Craig-Schapiro,Christopher M. Clark,Eve H. Pickering,Max Kuhn,Yu Chen,Vivianna M. Van Deerlin,Leo McCluskey,Lauren Elman,Jason Karlawish,Alice Chen-Plotkin,Howard I. Hurtig,Andrew Siderowf,Frank Swenson,Virginia M.-Y. Lee,John C. Morris,John Q. Trojanowski,Holly Soares +24 more
TL;DR: Four plasma analytes were consistently associated with the diagnosis of very mild dementia/MCI/AD in 3 independent clinical cohorts, and these plasma biomarkers may predict underlying AD through their association with CSF AD biomarkers.
Journal ArticleDOI
Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis
Rebecca Craig-Schapiro,Max Kuhn,Chengjie Xiong,Eve H. Pickering,Jingxia Liu,Thomas P. Misko,Richard J. Perrin,Kelly R. Bales,Holly Soares,Anne M. Fagan,David M. Holtzman +10 more
TL;DR: A targeted proteomics approach to discover novel cerebrospinal fluid (CSF) biomarkers that can augment the diagnostic and prognostic accuracy of current leading CSF biomarkers (Aβ42, tau, p-tau181) and identify a novel biomarker (calbindin) with significant prognostic potential.