Wendy Baker

TL;DR: It is shown that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical lymph nodes in mice and improves brain perfusion and learning and memory performance.

TL;DR: It is shown that meningeal immunity is also critical for social behaviour; mice deficient in adaptive immunity exhibit social deficits and hyper-connectivity of fronto-cortical brain regions, and suggests a co-evolutionary link between social behaviour and an anti-pathogen immune response driven by IFN-γ signalling.

TL;DR: In this article, the authors demonstrate that CSF-derived antigens in the cerebrospinal fluid accumulate around the dural sinuses, are captured by local antigen-presenting cells, and are presented to patrolling T-cells.

TL;DR: In this paper, the mouse meninges contain a pool of monocytes and neutrophils supplied not from the blood but by adjacent skull and vertebral bone marrow, which can originate from brain borders and display transcriptional signatures distinct from their blood derived counterparts.

TL;DR: A population of meningeal γδ17 T cells are characterized that use IL-17a to elicit anxiety-like behavior through cortical glutamatergic neurons, suggesting an evolutionary bridge between this conserved anti-pathogen molecule and survival behavioral traits in vertebrates.