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Bruno A. Benitez

Researcher at Washington University in St. Louis

Publications -  86
Citations -  5009

Bruno A. Benitez is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome-wide association study & Biology. The author has an hindex of 26, co-authored 68 publications receiving 3106 citations. Previous affiliations of Bruno A. Benitez include National University of Colombia & University of Washington.

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

Carlos Cruchaga, +79 more
- 23 Jan 2014 - 
TL;DR: The genetic and functional data indicate that carriers of PLD3 coding variants have a twofold increased risk for LOAD and thatPLD3 influences APP processing, and provides an example of how densely affected families may help to identify rare variants with large effects on risk for disease or other complex traits.
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GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease

Carlos Cruchaga, +36 more
- 24 Apr 2013 - 
TL;DR: In independent data sets, rs9877502 showed a strong association with risk for AD, tangle pathology, and global cognitive decline, illustrating how this endophenotype-based approach can be used to identify new AD risk loci.
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Coding variants in TREM2 increase risk for Alzheimer's disease

Sheng Chih Jin, +12 more
- 01 Nov 2014 - 
TL;DR: Gene-based tests demonstrate variants in TREM2 are genome-wide significantly associated with AD, and gel electrophoresis analysis confirms that at least three T REM2 transcripts are expressed in human brains, including one encoding a soluble form of TREM1.
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TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

Janet Cady, +14 more
- 01 Apr 2014 - 
TL;DR: This study demonstrates that the TREM2 p.R47H variant was more common in patients with ALS than in the controls and is therefore a significant risk factor for ALS, and highlights the T REM2 signaling pathway as a therapeutic target in ALS and other neurodegenerative diseases.