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Anthony J. Filiano
Researcher at Duke University
Publications - 44
Citations - 2686
Anthony J. Filiano is an academic researcher from Duke University. The author has contributed to research in topics: Medicine & Mesenchymal stem cell. The author has an hindex of 18, co-authored 30 publications receiving 2123 citations. Previous affiliations of Anthony J. Filiano include Durham University & University of Pittsburgh.
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Journal ArticleDOI
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
Anthony J. Filiano,Yang Xu,Nicholas J. Tustison,Rachel Marsh,Wendy Baker,Igor Smirnov,Christopher C. Overall,Sachin P. Gadani,Stephen D. Turner,Zhiping Weng,Sayeda Najamussahar Peerzade,Hao Chen,Kevin S. Lee,Michael Scott,Mark P. Beenhakker,Vladimir Litvak,Jonathan Kipnis +16 more
TL;DR: It is shown that meningeal immunity is also critical for social behaviour; mice deficient in adaptive immunity exhibit social deficits and hyper-connectivity of fronto-cortical brain regions, and suggests a co-evolutionary link between social behaviour and an anti-pathogen immune response driven by IFN-γ signalling.
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Glutamate Decreases Mitochondrial Size and Movement in Primary Forebrain Neurons
TL;DR: These studies demonstrate that in addition to altering the bioenergetic properties of mitochondria, neurotoxins can also alter mitochondrial movement and morphology and speculate that neurotoxin-mediated impairment of mitochondrial delivery may contribute to the injurious effects of neurotoxin.
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Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
James C. Cronk,Anthony J. Filiano,Antoine Louveau,Ioana Marin,Rachel Marsh,Emily Ji,Dylan H. Goldman,Igor Smirnov,Nicholas S. Geraci,Scott T. Acton,Christopher C. Overall,Jonathan Kipnis +11 more
TL;DR: It is demonstrated that therapeutic engraftment of brain-engrafting macrophages may be possible with irradiation-free conditioning regimens and that beM&phgr;s maintain a unique functional and transcriptional identity as compared with microglia.
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Myeloid Cells in the Central Nervous System.
TL;DR: The neuroprotective nature of certain myeloid cells are highlighted by emphasizing their therapeutic potential for the treatment of neurological conditions and the role of these cells in various neurological pathologies, such as autoimmunity, mechanical injury, neurodegeneration, and infection are discussed.
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ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects
Haiyan Qiu,Haiyan Qiu,Sebum Lee,Sebum Lee,Yulei Shang,Yulei Shang,Wen-Yuan Wang,Kin Fai Au,Sherry Kamiya,Sherry Kamiya,Sami J. Barmada,Steven Finkbeiner,Hansen Lui,Hansen Lui,Caitlin E. Carlton,Caitlin E. Carlton,Amy A. Tang,Amy A. Tang,Michael C. Oldham,Hejia Wang,James Shorter,Anthony J. Filiano,Erik D. Roberson,Warren G. Tourtellotte,Bin Chen,Li-Huei Tsai,Eric J. Huang,Eric J. Huang +27 more
TL;DR: Insight is provided into how gain-of-function FUS mutations affect critical neuronal functions in mice by screening neural genes for nucleotide oxidation and identifying brain-derived neurotrophic factor as a target of FUS-R521C-associated DNA damage and RNA splicing defects.